Rational Design of Non-Hydroxamate Histone Deacetylase Inhibitors

Title: Rational Design of Non-Hydroxamate Histone Deacetylase Inhibitors

Volume: 6 Issue: 5

Author(s): Takayoshi Suzuki and Naoki Miyata

Affiliation:

Keywords: Histone deacetylase, inhibitor, hydroxamic acid, non-hydroxamate, zinc enzyme, rational drug design, anticancer agent

Abstract: While most inhibitors of histone deacetylases (HDACs) are hydroxamic acid derivatives, several nonhydroxamates have recently been developed as inhibitors and attracted quite a deal of attention. In this review, we present the rational design, inhibitory effect and antiproliferative activity of non-hydroxamate HDAC inhibitors.

Cite this article as:

Suzuki Takayoshi and Miyata Naoki, Rational Design of Non-Hydroxamate Histone Deacetylase Inhibitors, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876186