Insights into Amyloid Fibril Formation from Mass Spectrometry

Gemma   L.   Caddy; Carol   V.   Robinson

doi:10.2174/092986606775338416

Abstract

Mass spectrometry has become increasingly important in amyloid research specifically in the mechanism of formation and characterization of fibrils. In this review we highlight key experiments that provide evidence for different conformations, interactions and unfolding intermediates in proteins associated with amyloid diseases.

Keywords: Mass spectrometry, amyloidogenic, hydrogen exchange, protein conformation

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