Amyloid Under the Atomic Force Microscope

Title: Amyloid Under the Atomic Force Microscope

Volume: 13 Issue: 3

Author(s): Walraj S. Gosal, Sarah L. Myers, Sheena E. Radford and Neil H. Thomson

Affiliation:

Keywords: Tapping mode, contact mode, functional surfaces, time-lapse microscopy, 3D topography, self-assembly, amyloid fibrils, biomimetic environments

Abstract: The atomic force microscope (AFM) is a versatile instrument that can be used to image biological samples at nanometre resolution as well as to measure inter and intra-molecular forces in air and liquid environments. This review summarises the use of AFM applied to protein and peptide self-assembly systems involved in amyloid formation. The technical principles of the AFM are outlined and its advantages and disadvantages are highlighted and discussed in the context of the rapidly developing field of amyloid research.

Cite this article as:

Gosal S. Walraj, Myers L. Sarah, Radford E. Sheena and Thomson H. Neil, Amyloid Under the Atomic Force Microscope, Protein & Peptide Letters 2006; 13 (3) . https://dx.doi.org/10.2174/092986606775338498