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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Modified Microwave-assisted Solid-liquid Halex Reaction using Phosphonium Salt as Efficient and Robust Phase Transfer Catalyst

Author(s): Dhanaji M. Mohite, Pandurang M. Chavhan and Arghya Basu*

Volume 28, Issue 20, 2024

Published on: 09 July, 2024

Page: [1605 - 1612] Pages: 8

DOI: 10.2174/0113852728311593240626091836

Price: $65

Abstract

A modified solid-liquid halex reaction was developed in the presence of a robust phase transfer catalyst under microwave conditions. A fast, mild, and practical microwave- assisted synthesis of 2,3-difluoro-5-chloropyridine 3 starting from 2,3,5- trichlorpyridine 1 and spray-dried KF in polar aprotic solvent was developed. The addition of Tetrakis (piperidino) phosphonium chloride as phase transfer catalyst A was studied under microwave irritation (450W) and increased the yield and significantly reduced the reaction time in contrast to the conventional heating procedure. The highest reaction rate was observed at 5 wt% phase transfer phosphonium salt catalyst to 2,3,5-trichloropyridine 1.

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