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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Microwave-assisted Synthesis of Pyrroles, Pyridines, Chromenes, Coumarins, and Betti Bases via Alcohol Dehydrogenation with Chroman-4-one Amino Ligands

Author(s): Danish Khan*, Beauty Kumari, Abdullah Yahya Abdullah Alzahrani, Neha Dua, Shaily and Nirma Maurya*

Volume 28, Issue 20, 2024

Published on: 11 July, 2024

Page: [1593 - 1604] Pages: 12

DOI: 10.2174/0113852728304957240628180342

Price: $65

Abstract

This study outlines the development of a novel approach utilizing microwave assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt (II) in conjunction with chroman-4-one amino ligands. This research introduces a unique catalytic system capable of synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, and coumarins via alcohol dehydrogenation. The synthesis involved the preparation and characterization of a series of chroman- 4-one amino ligands (C1-C6) using standard analytical techniques. These ligands, in combination with MnCl2‧4H2O and CoCl2, demonstrated remarkable catalytic activity, effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the in-situ formation of metal complexes with the ligands during the reaction. Characterization using ESI-MS confirmed the presence of metal complexes (Int-1) and other intermediates (Int-II and Int-III) throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of the catalytic system, evidenced by the evolution of H2 gas.

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