Abstract
Metabolic disorders have long been a challenge for medical professionals and are a leading cause of mortality in adults. Diabetes, cardiovascular disorders (CVD), renal dysfunction, and ischemic stroke are the most prevalent ailments contributing to a high mortality rate worldwide. Reactive oxygen species are one of the leading factors that act as a fundamental root cause of metabolic syndrome. All of these disorders have their respective treatments, which, to some degree, sabotage the pathological worsening of the disease and an inevitable death. However, they pose a perilous health hazard to humankind. Cysteine, a functional amino acid shows promise for the prevention and treatment of metabolic disorders, such as CVD, Diabetes mellitus, renal dysfunction, and ischemic stroke. In this review, we explored whether cysteine can eradicate reactive oxygen species and subsequently prevent and treat these diseases.
Graphical Abstract
[http://dx.doi.org/10.4103/0970-2113.184871] [PMID: 27578930]
[http://dx.doi.org/10.1016/j.cegh.2020.03.018]
[http://dx.doi.org/10.3390/molecules27227728] [PMID: 36431829]
[http://dx.doi.org/10.1007/s00726-013-1500-6]
[http://dx.doi.org/10.1016/j.diabres.2017.07.023] [PMID: 28783532]
[http://dx.doi.org/10.2174/1872312814666211210111820] [PMID: 34895129]
[http://dx.doi.org/10.21037/atm.2018.12.12] [PMID: 30740402]
[http://dx.doi.org/10.1053/j.gastro.2013.11.001] [PMID: 24211299]
[http://dx.doi.org/10.1155/2019/8267234] [PMID: 31191805]
[http://dx.doi.org/10.1016/j.tips.2018.02.007] [PMID: 29530337]
[http://dx.doi.org/10.1038/s41422-023-00800-8] [PMID: 37055592]
[http://dx.doi.org/10.3390/ijms151121202] [PMID: 25407526]
[http://dx.doi.org/10.1016/j.coph.2007.04.005] [PMID: 17602868]
[http://dx.doi.org/10.1016/j.bbadis.2016.11.010] [PMID: 27836629]
[http://dx.doi.org/10.1002/fsn3.1818] [PMID: 32994931]
[http://dx.doi.org/10.1021/cb3005269] [PMID: 23163700]
[http://dx.doi.org/10.1016/j.electacta.2013.03.023]
[http://dx.doi.org/10.3390/antiox10020169]
(b) Kader, T; Porteous, C Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein (a) mice. Atherosclerosis, 2014, 237(2), 725-733.
[PMID: 25463112]
[http://dx.doi.org/10.3390/antiox10060967] [PMID: 34208683]
[http://dx.doi.org/10.1016/j.mgene.2019.100612]
[http://dx.doi.org/10.1099/mic.0.077826-0]
[PMID: 30007014]
[http://dx.doi.org/10.1186/1475-2891-12-144] [PMID: 24195518]
[http://dx.doi.org/10.3390/biom12111712] [PMID: 36421725]
[http://dx.doi.org/10.3390/biomedicines10030574] [PMID: 35327376]
[http://dx.doi.org/10.1111/acel.13034] [PMID: 31460700]
[http://dx.doi.org/10.3390/biom12040542] [PMID: 35454131]
[http://dx.doi.org/10.1155/2015/418681]
[http://dx.doi.org/10.1016/j.chembiol.2018.01.011] [PMID: 29429900]
[http://dx.doi.org/10.1016/j.cnd.2018.06.002]
[http://dx.doi.org/10.1089/met.2015.0088] [PMID: 26859464]
[PMID: 30739804]
[http://dx.doi.org/10.1159/000452574] [PMID: 27898405]
[http://dx.doi.org/10.1016/j.numecd.2011.05.001] [PMID: 21764273]
[PMID: 28367412]
[http://dx.doi.org/10.1155/2012/271028]
[http://dx.doi.org/10.1016/j.freeradbiomed.2021.05.025] [PMID: 34019934]
[http://dx.doi.org/10.1590/1806-9282.63.01.85] [PMID: 28225880]
[PMID: 23770795]
[http://dx.doi.org/10.1016/j.freeradbiomed.2010.11.029] [PMID: 21130865]
[http://dx.doi.org/10.1177/0003319720916301] [PMID: 32242451]
[http://dx.doi.org/10.3390/nu11092090] [PMID: 31487802]
[http://dx.doi.org/10.3390/antiox10091486] [PMID: 34573117]
[http://dx.doi.org/10.4330/wjc.v6.i6.462] [PMID: 24976919]
[http://dx.doi.org/10.1016/j.apjtm.2017.10.017] [PMID: 29268965]
[http://dx.doi.org/10.33549/physiolres.932388] [PMID: 23234413]
[http://dx.doi.org/10.1186/s13643-017-0493-8] [PMID: 28499416]
[http://dx.doi.org/10.1016/j.jnutbio.2005.05.013] [PMID: 16111877]
[http://dx.doi.org/10.1177/0748233715571152] [PMID: 25731901]
[http://dx.doi.org/10.1038/s41569-018-0007-y] [PMID: 29674714]
[http://dx.doi.org/10.1016/j.tcm.2013.12.001] [PMID: 24373981]
[http://dx.doi.org/10.14235/bas.galenos.2017.2145]
[http://dx.doi.org/10.4330/wjc.v7.i11.719] [PMID: 26635921]
[http://dx.doi.org/10.1007/s11883-017-0678-6] [PMID: 28921056]
[http://dx.doi.org/10.2174/1871530322666211220110810]
[http://dx.doi.org/10.1515/hsz-2018-0397] [PMID: 30864421]
[http://dx.doi.org/10.3390/antiox12122073] [PMID: 38136193]
[http://dx.doi.org/10.1186/1475-2891-14-6] [PMID: 25577237]
[http://dx.doi.org/10.3390/antiox10060931] [PMID: 34201261]
[PMID: 26199914]
[http://dx.doi.org/10.3389/fphar.2016.00397] [PMID: 27881962]
[http://dx.doi.org/10.1016/j.carpath.2011.11.007] [PMID: 22227365]
[http://dx.doi.org/10.1002/ejhf.1320] [PMID: 30338885]
[http://dx.doi.org/10.1007/s11033-020-05907-4] [PMID: 33048324]
[http://dx.doi.org/10.1136/bmj.l6983] [PMID: 32054610]
[http://dx.doi.org/10.1016/j.nbd.2019.104613] [PMID: 31525435]
[http://dx.doi.org/10.1002/brb3.208] [PMID: 24683506]
[http://dx.doi.org/10.3390/genes11010089] [PMID: 31941075]
[http://dx.doi.org/10.1016/j.neuint.2011.11.009]
[http://dx.doi.org/10.1016/j.phrs.2020.104877] [PMID: 32407958]
[http://dx.doi.org/10.1097/MD.0000000000005593] [PMID: 27930580]
[http://dx.doi.org/10.3390/life11020080] [PMID: 33499230]
[PMID: 24294813]
[http://dx.doi.org/10.1007/s12975-019-00707-w] [PMID: 31049841]
[http://dx.doi.org/10.1161/01.STR.0000229883.72010.e4] [PMID: 16809576]
[PMID: 33957000]
[http://dx.doi.org/10.1016/j.neuint.2016.12.007] [PMID: 28043837]
[http://dx.doi.org/10.3109/14767058.2010.497879] [PMID: 20617896]
[http://dx.doi.org/10.3390/ijms21176026] [PMID: 32825703]
[http://dx.doi.org/10.1038/s41572-018-0051-2] [PMID: 30617281]
[http://dx.doi.org/10.1016/j.ejphar.2016.11.033] [PMID: 27887948]
[http://dx.doi.org/10.4239/wjd.v6.i4.598] [PMID: 25987957]
[http://dx.doi.org/10.1002/dmrr.2558] [PMID: 24845883]
[http://dx.doi.org/10.4093/dmj.2013.37.2.106] [PMID: 23641350]
[http://dx.doi.org/10.2174/1573399811309030005] [PMID: 23547683]
[http://dx.doi.org/10.1080/13813455.2016.1273365] [PMID: 28100069]
[http://dx.doi.org/10.1016/S0140-6736(21)00519-5] [PMID: 34175022]
[http://dx.doi.org/10.1155/2014/674987] [PMID: 24883061]
[http://dx.doi.org/10.1155/2021/9949453] [PMID: 34221501]
[http://dx.doi.org/10.1155/2015/515042]
[http://dx.doi.org/10.1016/j.preteyeres.2015.08.001] [PMID: 26297071]
[http://dx.doi.org/10.1038/eye.2017.64] [PMID: 28452994]
[http://dx.doi.org/10.1016/j.bbadis.2015.08.001]
[http://dx.doi.org/10.1007/s11033-011-1148-9] [PMID: 21952821]
[http://dx.doi.org/10.1007/978-1-4939-9841-8_1]
[http://dx.doi.org/10.1016/j.freeradbiomed.2017.12.040] [PMID: 29305106]
[http://dx.doi.org/10.1016/j.niox.2018.05.003] [PMID: 29778909]
[http://dx.doi.org/10.1016/j.jdiacomp.2020.107834]
[http://dx.doi.org/10.1111/j.1440-1797.2012.01572.x] [PMID: 22288610]
[http://dx.doi.org/10.1016/j.lfs.2016.03.003] [PMID: 26946308]
[http://dx.doi.org/10.18632/oncotarget.8341] [PMID: 27029038]
[http://dx.doi.org/10.1021/acs.chemrestox.9b00152] [PMID: 31046246]
[http://dx.doi.org/10.1007/s12020-013-0056-2] [PMID: 24065310]
[http://dx.doi.org/10.1590/1806-9282.66.s1.3] [PMID: 31939529]
[http://dx.doi.org/10.1007/s00467-018-4005-4] [PMID: 30105414]
[http://dx.doi.org/10.1186/s41100-018-0195-2]
[http://dx.doi.org/10.4103/1319-2442.174084] [PMID: 26787572]
[http://dx.doi.org/10.5455/msm.2015.27.95-98] [PMID: 26005384]
[http://dx.doi.org/10.1016/bs.acc.2015.07.002] [PMID: 26471081]
[http://dx.doi.org/10.1152/japplphysiol.00167.2015] [PMID: 26472863]
[http://dx.doi.org/10.1016/S0022-5223(03)00968-1] [PMID: 14666027]
[http://dx.doi.org/10.1038/labinvest.2011.146] [PMID: 21968809]
[http://dx.doi.org/10.1016/S0006-8993(03)02244-3] [PMID: 12691831]
[http://dx.doi.org/10.1016/j.ajem.2016.06.003] [PMID: 27324856]
[http://dx.doi.org/10.3109/01480545.2011.564179] [PMID: 21770721]
[http://dx.doi.org/10.1111/j.1471-4159.2009.06435.x] [PMID: 19840221]
[http://dx.doi.org/10.1111/j.1523-1755.2005.00677.x] [PMID: 16221220]
[http://dx.doi.org/10.1093/ndt/gfn090] [PMID: 18385389]
[http://dx.doi.org/10.2147/NDT.S241497] [PMID: 32547030]
[http://dx.doi.org/10.1016/j.ahj.2006.02.002] [PMID: 16644332]
[http://dx.doi.org/10.1097/01.CCM.0000295305.22281.1D] [PMID: 18090169]
[http://dx.doi.org/10.1016/j.ejim.2017.06.011] [PMID: 28633804]
[http://dx.doi.org/10.1007/s40256-013-0048-x] [PMID: 24105017]
[http://dx.doi.org/10.1371/journal.pone.0213862] [PMID: 31071081]
[http://dx.doi.org/10.21608/aijpms.2023.155638.1159]