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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Review Article

The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer

Author(s): Songhua Liu, Yao Rong, Mingzheng Tang, Qiqi Zhao, Chunyan Li, Wenbin Gao and Xiaojun Yang*

Volume 27, Issue 18, 2024

Published on: 11 October, 2023

Page: [2639 - 2653] Pages: 15

DOI: 10.2174/0113862073268591230928100922

Price: $65

Abstract

Gastric cancer (GC) is one of the most common malignancies worldwide. Despite significant advancements in surgical and adjuvant treatments, patient prognosis remains unsatisfactory. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that lack protein-coding capacity but can engage in the malignant biological behaviors of tumors through various mechanisms. Among them, small nucleolar host genes (SNHGs) represent a subgroup of lncRNAs. Studies have revealed their involvement not only in gastric cancer cell proliferation, invasion, migration, epithelial- mesenchymal transition (EMT), and apoptosis but also in chemotherapy resistance and tumor stemness. This review comprehensively summarizes the biological functions, molecular mechanisms, and clinical significance of SNHGs in gastric cancer. It provides novel insights into potential biomarkers and therapeutic targets for the exploration of gastric cancer.

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