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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Review Article

Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives

Author(s): Rezvan Mohammadi, Sepideh Ghani, Roghaye Arezumand, Shohreh Farhadi, Yalda Khazaee-poul, Bahram Kazemi*, Fatemeh Yarian*, Somaye Noruzi, Abbas Alibakhshi, Mahsa Jalili and Shahin Aghamiri

Volume 24, Issue 10, 2024

Published on: 18 October, 2023

Page: [1250 - 1268] Pages: 19

DOI: 10.2174/1566524023666230818093016

Price: $65

Abstract

The application of monoclonal antibodies and antibody fragments with the advent of recombinant antibody technology has made notable progress in clinical trials to provide a regulated drug release and extra targeting to the special conditions in the function site. Modification of antibodies has facilitated using mAbs and antibody fragments in numerous models of therapeutic and detection utilizations, such as stimuliresponsive systems. Antibodies and antibody derivatives conjugated with diverse stimuliresponsive materials have been constructed for drug delivery in response to a wide range of endogenous (electric, magnetic, light, radiation, ultrasound) and exogenous (temperature, pH, redox potential, enzymes) stimuli. In this report, we highlighted the recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive systems that affect modern medicine by improving a multitude of diagnostic and treatment strategies.

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