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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Review Article

Genetic Aspects of Glaucoma: An Updated Review

Author(s): Oscar Francisco Chacon-Camacho, Rocio Arce-Gonzalez, Fernanda Sanchez-de la Rosa, Andrés Urióstegui-Rojas, María Enriqueta Hofmann-Blancas, Felipe Mata-Flores and Juan Carlos Zenteno*

Volume 24, Issue 10, 2024

Published on: 17 October, 2023

Page: [1231 - 1249] Pages: 19

DOI: 10.2174/1566524023666230602143617

Price: $65

Abstract

Glaucoma is a group of diverse diseases characterized by cupping of the optic nerve head due to the loss of retinal ganglion cells. It is the most common cause of irreversible blindness throughout the world; therefore, its timely diagnosis and early detection through an ophthalmological examination are very important. We, herein, present the information on the epidemiology, pathophysiology, clinical diagnosis, and treatment of glaucoma. We also emphasize the investigations of the last decades that have allowed identifying numerous genes and susceptibility genetic factors. We have also described in detail the genes whose mutations cause or contribute to the development of the disease.

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