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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Radiotherapy-associated Sensorineural Hearing Loss in Pediatric Oncology Patients

Author(s): Muhammad Ammar Aslam, Hassaan Ahmad, Hamza Sultan Malik, Herlina Uinarni, Yasir Salam Karim, Yusuf Makhmudovich Akhmedov, Walid Kamal Abdelbasset, Sura A. Awadh, Mohammed Kadhem Abid, Yasser Fakri Mustafa, Bagher Farhood* and Amirhosein Sahebkar*

Volume 31, Issue 33, 2024

Published on: 22 June, 2023

Page: [5351 - 5369] Pages: 19

DOI: 10.2174/0929867330666230515112245

Price: $65

Abstract

During the radiotherapeutic treatment of pediatric oncology patients, they would be at a latent risk of developing ionizing radiation-induced ototoxicity when the cochlea or auditory nerve is located within the radiation field. Sensorineural hearing loss (SNHL) is an irreversible late complication of radiotherapy, and its incidence depends on various factors such as the patient’s hearing sensitivity, total radiation dose to the cochlea, radiotherapy fractionation regimen, age and chemoradiation. Importantly, this complication exhibits serious challenges to adult survivors of childhood cancer, as it has been linked to impairments in academic achievement, psychosocial development, independent living skills, and employment in the survivor population. Therefore, early detection and proper management can alleviate academic, speech, language, social, and psychological morbidity arising from hearing deficits. In the present review, we have addressed issues such as underlying mechanisms of radiation-induced SNHL, audiometric findings of pediatric cancer patients treated with radiotherapy, and management and protection measures against radiation-induced ototoxicity.

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