Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker

Title: Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker

Volume: 6 Issue: 4

Author(s): P. J. Blankestijn and H. Rupp

Affiliation:

Keywords: Eprosartan, hypertension, sympathetic nervous system, renin angiotensin system

Abstract: Rationale. The goal of antihypertensive treatment is to reduce risk of cardiovascular morbidity and mortality. Apart from blood pressure lowering per se, also reducing the activities of the renin-angiotensin system and sympathetic nervous system appears to be important. Angiotensin II receptor blocker drugs (ARBs) have provided a useful class of anti-hypertensive drugs. Eprosartan is a relatively new ARB which is chemically distinct (non-biphenyl, non-tetrazole) from all other ARBs (biphenyl tetrazoles). An analysis has been made on available experimental and clinical data on eprosartan which not only is an effective and well tolerated antihypertensive agent, but also lowers the activities of the renin-angiotensin system and sympathetic nervous system. Experimental and pharmacokinetic studies on eprosartan have shown differences with the other ARBs. The distinct properties of this non-biphenyl, non-tetrazole ARB might be relevant in the effort to reduce cardiovascular risk, also beyond its blood pressure lowering capacity.

Cite this article as:

Blankestijn J. P. and Rupp H., Clinical Profile of Eprosartan: A Different Angiotensin II Receptor Blocker, Cardiovascular & Hematological Agents in Medicinal Chemistry 2008; 6 (4) . https://dx.doi.org/10.2174/187152508785909500