Targeting Ferroptosis Pathways: A Novel Strategy for Cancer Therapy

doi:10.2174/1568009622666220211122745
摘要

Ferroptosis 是一种铁依赖性非凋亡性细胞死亡，由细胞质中氧化还原平衡的破坏引起。与细胞凋亡不同，铁死亡是由细胞内铁和脂质过氧化物的增加引起的，这些过氧化物对膜脂双层和线粒体造成显着损害，导致细胞死亡。细胞中铁水平的增加促进了 ROS 的产生。铁死亡诱导剂分子增加 ROS 的产生并抑制抗氧化防御机制以促进癌细胞中的铁死亡。 GPX4 的抑制、氧化还原活性铁的可用性和脂质过氧化是导致铁死亡的主要因素。铁死亡与许多疾病有关，如心脏病、神经退行性疾病和癌症。铁死亡诱导最近成为一种有吸引力的癌症治疗策略。在这篇综述中，我们讨论了铁死亡的调控机制，其不同的标志，包括促进癌细胞铁死亡的遗传和代谢调节剂和诱导剂。最后，讨论了不同癌症中铁死亡研究的最新进展和发展，重点是提出癌症治疗的新策略。
关键词: 铁死亡、癌症、氧化还原失衡、调节细胞死亡、标志物、诱导剂。
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图形摘要

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DOI https://dx.doi.org/10.2174/1568009622666220211122745	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576
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