Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders

Title:Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders

Volume: 29 Issue: 16

Author(s): Farzaneh Shakeri, Bahram Bibak, Mohammad Reza Safdari, Zakieh Keshavarzi, Tannaz Jamialahmadi, Thozhukat Sathyapalan*Amirhossein Sahebkar*

Affiliation:

• Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

• Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
• Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
• Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
• School of Medicine, The University of Western Australia, Perth, Australia

Keywords: Curcumin, thyroid gland, molecular mechanisms, hormones, thyrotropin, pituitary gland.

Abstract: There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The role of curcumin in thyroid gland disorders has been demonstrated by its effects on various biological pathways, including anti-inflammatory, antioxidant, anti-proliferative, apoptosis, angiogenesis, cell cycle and metastasis. In this paper, we have reviewed the recent literature on curcumin applications for thyroid dysfunction, including hyperthyroidism and hypothyroidism, and discussed the molecular mechanisms of these effects. This review aims to summarize the wealth of research related to the therapeutic effect of curcumin on the thyroid gland.

Cite this article as:

Shakeri Farzaneh, Bibak Bahram, Safdari Reza Mohammad, Keshavarzi Zakieh, Jamialahmadi Tannaz, Sathyapalan Thozhukat*, Sahebkar Amirhossein*, Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders, Current Medicinal Chemistry 2022; 29 (16) . https://dx.doi.org/10.2174/0929867329666220210145033