Long Non-Coding RNA GAS5 in Age-Related Diseases

Title:Long Non-Coding RNA GAS5 in Age-Related Diseases

Volume: 29 Issue: 16

Author(s): Yaqi Wang, Mengzhen Xue, Fangqi Xia, Leiqi Zhu, Dengke Jia, Yan Gao, Luoying Li, Yue Shi, Yuanyang Li, Silong Chen, Guangfu Xu and Chengfu Yuan*

Affiliation:

• College of Medical Science, China Three Gorges University, Yichang 443002, China
• Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges, Yichang. Hubei 443002. China

Keywords: lncRNAs , GAS5 , age-related diseases , atherosclerosis , type 2 diabetes mellitus , cancer.

Abstract: Aging refers to a natural process and a universal phenomenon in all cells, tissues, organs, and the whole organism. Long non-coding RNAs (lncRNAs) are non-coding RNAs with a length of 200 nucleotides. LncRNA growth arrest-specific 5 (lncRNA GAS5) is often down-regulated in cancer. The accumulation of lncRNA GAS5 has been found to be able to inhibit cancer growth, invasion, and metastasis while enhancing the sensitivity of cells to chemotherapy drugs. LncRNA GAS5 can be a signaling protein, which is specifically transcribed under different triggering conditions. Subsequently, it is involved in signal transmission in numerous pathways as a signal node. LncRNA GAS5, with a close relationship to multiple miRNAs, was suggested to be involved in the signaling pathway under three action modes (i.e., signal, bait, and guidance). LncRNA GAS5 was found to be involved in different age-related diseases (e.g., rheumatoid arthritis, type 2 diabetes, atherosclerosis, osteoarthritis, osteoporosis, multiple sclerosis, cancer, etc.). This study mainly summarized the regulatory effect exerted by lncRNA GAS5 on age-related diseases.

Cite this article as:

Wang Yaqi , Xue Mengzhen , Xia Fangqi , Zhu Leiqi , Jia Dengke, Gao Yan , Li Luoying, Shi Yue , Li Yuanyang , Chen Silong , Xu Guangfu and Yuan Chengfu *, Long Non-Coding RNA GAS5 in Age-Related Diseases, Current Medicinal Chemistry 2022; 29 (16) . https://dx.doi.org/10.2174/0929867328666211027123932