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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

岩藻黄质对脑室内链脲佐菌素 (ICV-STZ) 诱导的实验大鼠认知障碍的神经保护作用

卷 18, 期 8, 2021

页: [623 - 637] 页: 15

弟呕挨: 10.2174/1567205018666211118144602

价格: $65

摘要

背景：阿尔茨海默病（AD）是一种神经系统疾病，其特征是由氧化应激、神经炎症、神经递质水平变化和 Aβ（1-42）斑块过度沉积引起的记忆和认知功能丧失。岩藻黄素是一种类胡萝卜素，具有潜在的抗氧化、抗炎和神经保护作用。目的：在本研究中，岩藻黄质被用作脑室链脲佐菌素（ICV-STZ）诱导的认知障碍实验模型的保护策略。 方法：STZ 在第 1 天和第 3 天交替注射两次 ICV (3 mg/kg)，并使用 Morris 水迷宫和高架十字迷宫评估 Wistar 大鼠的记忆分析。低 50 mg/kg 的岩藻黄质，口服和高剂量 100 mg/kg，口服给药14天。第29天处死所有动物，分离后的脑海马组织用于生化（MDA、亚硝酸盐、GSH、SOD和过氧化氢酶）、神经炎症（TNF-α、IL-1β和IL-6）、神经递质（ACh、 GABA 谷氨酸盐)、Aβ(1-42) 和 Tau 蛋白测量。 结果：注射 STZ 的大鼠表现出明显的学习和记忆障碍，氧化应激（MDA、亚硝酸盐）增加，抗氧化防御（GSH、SOD 和过氧化氢酶）降低，促进细胞因子释放和神经递质水平变化。然而，岩藻黄质改善了认知功能，恢复了抗氧化水平，剂量依赖性地减少了炎症标志物，并恢复了神经递质浓度。 结论：目前的研究结果表明，岩藻黄质可能是通过抗氧化、抗炎和神经保护机制以及抑制乙酰胆碱酯酶 (AChE) 酶活性、Aβ(1-42) 积累和τ蛋白。

关键词: 岩藻黄质、STZ、细胞因子、神经递质、乙酰胆碱酯酶、阿尔茨海默病。

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