Abstract
Viral proteins sometimes interfere with human transmembrane receptors to gain access into a cell or they use transmembrane domains to interfere with cellular signal cascades in human cells. Such interference can lead to a deregulation of tightly regulated processes and eventually to different forms of cancer. There is still little knowledge about how proteins act and interact in biological membranes but the membrane environment restricts the fold and composition of membrane proteins when compared to water soluble proteins. These restrictions and a sometimes related functional principle of different viral transmembrane proteins for gaining access to a host cell or to intervene with cellular processes may offer a great opportunity to interfere with those processes in a simplified manner. A close collaboration of various disciplines may result in the development of drugs that specifically target membranes and interfere with viral transmembrane domains or even regulate the function of cellular membrane proteins. In this review we describe the function of interactions between human and viral membrane proteins in a cellular membrane, and perspectives to intervene with those processes are discussed.
Keywords: Virus, membrane, peptide, fusion, receptor tyrosine kinase, HIV, SFFV, BPV
Current Medicinal Chemistry
Title: Lessons from Viruses: Controlling the Function of Transmembrane Proteins by Interfering Transmembrane Helices
Volume: 15 Issue: 8
Author(s): F. Cymer and D. Schneider
Affiliation:
Keywords: Virus, membrane, peptide, fusion, receptor tyrosine kinase, HIV, SFFV, BPV
Abstract: Viral proteins sometimes interfere with human transmembrane receptors to gain access into a cell or they use transmembrane domains to interfere with cellular signal cascades in human cells. Such interference can lead to a deregulation of tightly regulated processes and eventually to different forms of cancer. There is still little knowledge about how proteins act and interact in biological membranes but the membrane environment restricts the fold and composition of membrane proteins when compared to water soluble proteins. These restrictions and a sometimes related functional principle of different viral transmembrane proteins for gaining access to a host cell or to intervene with cellular processes may offer a great opportunity to interfere with those processes in a simplified manner. A close collaboration of various disciplines may result in the development of drugs that specifically target membranes and interfere with viral transmembrane domains or even regulate the function of cellular membrane proteins. In this review we describe the function of interactions between human and viral membrane proteins in a cellular membrane, and perspectives to intervene with those processes are discussed.
Export Options
About this article
Cite this article as:
Cymer F. and Schneider D., Lessons from Viruses: Controlling the Function of Transmembrane Proteins by Interfering Transmembrane Helices, Current Medicinal Chemistry 2008; 15 (8) . https://dx.doi.org/10.2174/092986708783955545
DOI https://dx.doi.org/10.2174/092986708783955545 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
2,3-Dichloro-1,4-Naphthoquinone in Organic Synthesis: Recent Advances
Mini-Reviews in Organic Chemistry Bone Imaging in Metastatic Castration-resistant Prostate Cancer; Where do we Stand
Current Radiopharmaceuticals Vitamin D Analogs in Cutaneous Malignancies
Current Pharmaceutical Design Investigation of Prevalence and Complications of Female Genital Circumcision: A Systematic and Meta-analytic Review Study
Current Pediatric Reviews Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy
Current Cancer Drug Targets Receptor Binding Inhibitor Suppresses Carcinogenesis of Cervical Cancer by Depressing Levels of FSHR and ERβ in Mice
Anti-Cancer Agents in Medicinal Chemistry Prothymosin α and its C-Terminal Immunoreactive Decapeptide Show No Evidence of Acute Toxicity: A Preliminary <i>In Silico</i>, <i>In Vitro</i> and <i>In Vivo</i> Investigation
Current Medicinal Chemistry KiSS1-Induced GPR54 Signaling Inhibits Breast Cancer Cell Migration and Epithelial-Mesenchymal Transition via Protein Kinase D1
Current Molecular Medicine LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers
Current Cancer Drug Targets Synthesis of Unsymmetrical C5-Curcuminoids as Potential Anticancer Agents
Letters in Drug Design & Discovery PLK1 Inhibition: Prospective Role for the Treatment of Pediatric Tumors
Current Drug Targets Comparative Proteomics of Liver of the Diabetic Obese db/db and Non-Obese or Diabetic Mice
Current Proteomics Harnessing the Power of Cerenkov Luminescence Imaging for Gastroenterology: Cerenkov Luminescence Endoscopy
Current Medical Imaging Therapeutic Potential of Essential Oil-based Microemulsions: Reviewing State-of-the-art
Current Drug Delivery In-Vitro Anticancer Evaluation and Docking Study of Novel Benzo[g] Quinazoline-sulfonamide Derivatives
Medicinal Chemistry Recent Advances on Prediction of Human Papillomaviruses Risk Types
Current Drug Metabolism Chemical Constituents and Biological Activities of Vietnamese Medicinal Plants
Current Topics in Medicinal Chemistry Safe and Effective Kinase Inhibitors for the Treatment of Gynecological Cancers: In Silico Approach
Current Drug Metabolism Homologation: A Versatile Molecular Modification Strategy to Drug Discovery
Current Topics in Medicinal Chemistry Effect of Oil Extract from Microalgae (<i>Schizochytrium</i> sp.) on the Viability and Apoptosis of Human Osteosarcoma Cells
Current Pharmaceutical Biotechnology