Cell-to-Cell Transmission of the Unfolded Protein Response - Is it a Real Phenomenon?

Title:Cell-to-Cell Transmission of the Unfolded Protein Response - Is it a Real Phenomenon?

Volume: 28 Issue: 22

Author(s): Maria Bozko and Przemyslaw Bozko*

Affiliation:

• Department of Internal Medicine I, Universitätsklinikum Tübingen, Tübingen,Germany

Keywords: Endoplasmic reticulum, unfolded protein response, conditioned media, UPR, unfolded protein, cell-tocell transmission, response.

Abstract: Cell-to-cell transmission of the unfolded protein response (UPR) is one of the most exciting observations recently made in cell biology. One of the most efficient tools to induce UPR response in cell culture is treatment with specific compounds leading to accumulation of misfolded proteins in endoplasmic reticulum. In this article we discussed opposite opinions regarding application of this approach and possible sources of experimental artefacts.

Cite this article as:

Bozko Maria and Bozko Przemyslaw *, Cell-to-Cell Transmission of the Unfolded Protein Response - Is it a Real Phenomenon?, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867327999201105163402