Potential Repurposing of Drugs with Anti-SARS-CoV-2 Activity in Preclinical Trials: A Systematic Review

Title:Potential Repurposing of Drugs with Anti-SARS-CoV-2 Activity in Preclinical Trials: A Systematic Review

Volume: 28 Issue: 22

Author(s): Yasmim Mendes Rocha, Gabriel Acácio de Moura, Juliana Ramos de Oliveira, Larissa Deadame de Figueiredo Nicolete and Roberto Nicolete*

Affiliation:

• Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Ceara (UFC), Fortaleza- CE,Brazil

Keywords: Covid-19, SARS-CoV-2, drugs, repurposing, antivirals, treatment.

Abstract: COVID-19 is an emerging outbreak similar to previous pandemics caused by Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Till date, SARS-CoV-2 infection is still spreading, representing a major threat to public health, where several control measures are being practiced in order to culminate its spread. The research and development of new drugs require a lot of funding in addition to being a slow and costly process. As a result, new techniques have been proposed to streamline this process. The repositioning or repurposing of drugs represents an attractive strategy, presenting a promising way to introduce new drugs. Currently, numerous reused drugs are already available in the market and are in practice. In this review, it was observed that the antiviral drugs Entricitabine and Tenofovir display potential therapeutic efficacy in preclinical studies. Therefore, in silico analyses were considered a potential tool for predicting the effectiveness of drugs, mainly as an effective approach to encourage a complementary in vitro and in vivo antiviral evaluation.

Cite this article as:

Rocha Mendes Yasmim , de Moura Acácio Gabriel , de Oliveira Ramos Juliana , de Figueiredo Nicolete Deadame Larissa and Nicolete Roberto *, Potential Repurposing of Drugs with Anti-SARS-CoV-2 Activity in Preclinical Trials: A Systematic Review, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867327666201005113204