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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

脱氢表雄酮（DHEA）及其硫酸盐（DHEAS）在阿尔茨海默氏病中的应用

卷 17, 期 2, 2020

页: [141 - 157] 页: 17

弟呕挨: 10.2174/1567205017666200317092310

价格: $65

摘要

背景：类固醇神经脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）参与许多重要的脑功能，包括神经元可塑性和存活，认知和行为，证明了在包括阿尔茨海默氏病在内的各种神经精神疾病和神经退行性疾病中的预防和治疗潜力。 目的：本文旨在提供有关DHEA和DHEAS参与阿尔茨海默氏病的文献的全面概述。 方法：在PubMed和MEDLINE数据库中搜索相关文献。选择文章时要考虑其标题和摘要。在所选的全文中，手动搜索了参考文献列表以查找其他文章。 结果：我们对研究DHEA和DHEAS在各种体外和动物模型以及阿尔茨海默氏病患者中的作用的研究进行了系统的综述，并对它们的潜在预防和治疗应用进行了全面讨论。 结论：尽管结果参差不齐，但各种临床前研究的结果普遍支持DHEA和DHEAS参与阿尔茨海默氏病的病理生理，这表明这些类固醇在预防和治疗方面具有潜在的益处。但是，到目前为止，小型临床试验几乎没有证据支持其在AD中的治疗。因此，在将其应用于临床之前，需要进行大规模的人体研究来阐明DHEA和DHEAS的特定作用及其作用机理。

关键词: 脱氢表雄酮，硫酸脱氢表雄酮，阿尔茨海默氏病，体外研究，动物模型，患者，治疗方法。

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