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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

针对Ryanodine受体翻译后重构:阿尔茨海默病治疗的新途径

卷 17, 期 4, 2020

页: [313 - 323] 页: 11

弟呕挨: 10.2174/1567205017666200225102941

价格: $65

摘要

与阿尔茨海默病(AD)相关的病理钙(Ca2+)信号通路涉及细胞内Ca2+释放通道/ryanodine受体(RyRs)。RyRs是一种大分子复合物，RyRs和几个调节蛋白之间的蛋白质-蛋白质相互作用影响通道功能。药理学和遗传学方法将RyRs大分子复合物的不稳定与包括大脑紊乱在内的一些人类病理联系起来。在这篇综述中，我们讨论了我们最近的数据，这些数据表明AD中增强的神经元RyR2介导的Ca2+泄漏与翻译后修饰(过度磷酸化、氧化和亚硝基化)相关，导致RyR2大分子复合物重塑，以及通道中稳定蛋白Calstabin2的解离。我们描述了RyR的大分子复杂结构，并讨论了AD中RyR2神经元重构的分子机制和信号级联。我们提供了RyR2功能障碍与AD中改变的肾上腺素能信号级联的证据。AD中RyR2的重塑导致组织病理学病变、突触可塑性改变、学习记忆缺陷。靶向RyR大分子复合物重构应被认为是治疗/或预防AD发生和/或进展的一个新的治疗窗口。

关键词: Ryanodine受体

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