Introduction to Molecular Genomics

This chapter proposes a brief description of deoxyribonucleic acid: Molecule of life eventually decode; Molecular organization of Genome; Evolutionary journey of a single cell to a multiplex form of life; Genome Replication; deoxyribonucleic acid Damage, Mutations and Repair.

This chapter proposes a brief description of: From Gene to Protein; Regulation of Gene Expression; Value of Diversity; Gene evolution: Divergence of sequences and structures within and between species; Economic and national needs of biodiversity; Conservational efforts for sustainable ecosystem.

This chapter proposes a brief description of DNA Polymerization; Genomic Finger Printing; DNA Sequencing; Comparative, Structural and Functional Genomics: A Triode; Proteomics; Metabolomics; Microarrays & Transcriptomics; Genome-wide association study.

This chapter proposes a brief description of Genetic Modifications of Farm Animals; Strategies for Gene Manipulation; Selection, Screening, and Analysis of Recombination; Transgenic Livestock; Animal Cloning; Biotechnology Applications of rDNA Technology.

This chapter proposes a brief description of Epigenetics; Role of DNA, RNA and Chromatin; Epigenetic regulation of Chromosomal Inheritances; Structural & Biochemical Advances in Mammalian DNA Methylation; Histones Modifications; Epigenomics.

This chapter proposes a brief description of the concept of pan-genomics; Computation approaches in pan-genomics and challenges; Applications of pangenomics; Evolutionary pan-genomics and its perspectives; Pan-genomics for cancer prevention and its prospects; Pan-genomics of pathogens and its applications; Pangenome analysis of microorganisms; Plant Pan-genomics.

This chapter proposes a brief description of the Role of Bioinformatics in the Post-Genomic Era; Digital Sequence Repositories; From the World of 1D to the era of 3D (Protein Structures); Functional Genomics; Sequence Alignment, Phylogeny, and concept of gene evolution; Sequence and structural alignment; Genomics of personalized medicine; CADD: Computer-Aided Drug Designing; Big Data Analysis; Responsible Genomic data sharing.

This chapter proposes a brief description of Human genome Project; Budget and Goals of Human Genome Project; Human Genome Project Timeline; Science behind Human Genome Project; Advances based on Human Genome Project; Human Genome Project Impact; Influence of human genome project on biological and technological progress; Medicinal Impact; Effect on law and the sociologies; Technical Aspects of Human Genome Project; Mapping Strategies; Sequencing Strategies; Findings of Human genome Project; Post Human Genome Project era: What is to come.

This chapter proposes a brief description of Possible health enhancement; Genome-wide association studies (GWAS); GWAS and different case studies; Nextgeneration sequencing (NGS); Steps of Next-generation DNA sequencing; DNA library preparation, Amplification, Emulsion PCR, Bridge PCR, Sequencing; Impacts of Genomic in Future Health; Cancer: stratifying tumors for treatment; Drug prescription and development; Diagnosing and characterizing genetic disease; From disease diagnosis to personalized genetic health; Integrating genomic and clinical information; Economic benefits of genomic medicine; Targeted genome editing: a new era in modern genomics; Modifying the Genome Through Nucleases; Zinc Finger Nucleases, Transcription Activator-like Effector Nucleases, Clustered Regularly Interspaced Short Palindromic Repeats / Cas9 (CRISPR/Cas 9), Delivering the Nucleases; Application of Engineered Nucleases; Personalized Medicine; Epigenome.

This chapter proposes a brief description of Ethical values of advancement in science; Moral perspective of animal cloning; Social responses towards scientific interventions; The Do's and DON'Ts.