Abstract
Since ancient times, olive oil has been part of human culture. It is the main
source of fatty acids in the Mediterranean diet and has beneficial effects on human
health. Due to its high content of monounsaturated fatty acids (MUFA),
polyunsaturated fatty acids (PUFA) and polyphenols, it is generally considered one of
the best sources of fat. Among its health properties, olive oil can counteract LDL
cholesterol, and protect against cardiovascular diseases and furthermore, its
biomolecules (such as polyphenols) can positively interact with oxidative stress,
carcinogenesis and arteriosclerosis. Oleuropein and hydroxytyrosol (HTyr) are
characteristic phenols of olive oil. Oleuropein is hydrolyzed by endogenous βglycosidases to produce HTyr. The beneficial effect of olive oil on oxidative stress is
largely due to HTyr and its derivatives. Furthermore, HTyr exhibits antioxidant,
antitumor, anti-inflammatory, cardioprotective and neuroprotective activities. The
search for synthetic compounds derived from HTyr can be an interesting way to
enhance their biological activities and / or to discover other properties. HTyr can be
obtained from crusher wastewater, which is considered a good source of Htyr.
Keywords: Biological assets, Health benefits, Hydroxytyrosol, Hydroxytyrosol derivatives, MUFA, Olea europaea, Oleuropein, Olive oil, Polyphenols.