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Medical Applications of Beta-Glucan

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Beta Glucan for the Treatment Of Vulvovaginal Candidiasis (VVC) and Recurrent Vulvovaginal Candidiasis (RVVC)

Author(s): Betül Gürünlü

Pp: 121-129 (9)

DOI: 10.2174/9789815039238122010015

* (Excluding Mailing and Handling)

Abstract

Vulvovaginal candidiasis (VVC) is one of the most common infections in
women. It is one of the most common fungal infections with Candida albicans (C.
albicans) as the major causative agent in humans. C. albicans is an opportunistic fungal
pathogen and a normal colonizer of the intestinal mucosa, oral cavity, and vulvovaginal
tract [1]. Overgrowth of the fungus followed by epithelial invasion and immune cell
infiltration leads to inflammatory symptoms such as vaginal itching, burning, and pain.
These clinical representations reduce the quality of life and cause high costs in the
global health system [2]. It is known that the fungus-glucan is highly immunoreactive
[3] and that β-glucan masking by mannan can inhibit the recognition and killing of
fungi by macrophages [4-6]. The aim of this study was to evaluate the ability of β-
glucan to protect against C. albicans vaginal infection.

Keywords: β-glucan, Beta Glucan, Vaginal Candidiasis, Vulvovaginal Candidiasis

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