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Medical Applications of Beta-Glucan

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Beta Glucan for the Treatment of Human Papilloma Virus (HPV) and Cervical Cancer

Author(s): Betül Gürünlü

Pp: 130-142 (13)

DOI: 10.2174/9789815039238122010016

* (Excluding Mailing and Handling)

Abstract

Cervical cancer is the fourth most frequently diagnosed cancer. For the
treatment of this relentless disease, chemotherapy is the most widely applied cure now.
However, this treatment carries some important side effects, such as neutropenia which
having an abnormally low concentration of neutrophils in the blood. Also,
chemotherapeutic drugs cause harm to blood formation. Therefore, chemotherapy
affects the patients’ immune system badly by making them open to infections. Another
treatment method is radiotherapy for the healing of cervical cancer. This technique also
carries some side effects being hematopoietic and harm to the immune system. Betaglucans
modulates the immune system by affecting a wide range of cells like antigenpresenting
cells (APCs), including macrophages, dendritic cells, T cells, monocytes. It
regulates both adaptive and innate immune systems. It has different kinds such as
sizofiran (SPG), zymosan, curdlan, and PBG to prevent and protect from cervical
cancer. Beta-glucan provides a novel therapeutic method for the healing of human
papillomavirus (HPV) and cervical cancer.

Keywords: β-glucan, Beta Glucan, Human Papilloma Virus

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