Biologically Active Natural Products from Asia and Africa: A Selection of Topics

Antilithiatic Properties of Moroccan Medicinal Plants and Mechanism Insights of their Phytochemicals

Author(s): Aya Khouchlaa, ">Abdelhakim Bouyahya and M`hamed Tijane

Pp: 67-83 (17)

DOI: 10.2174/9789811489747121010009

* (Excluding Mailing and Handling)

Abstract

The transition from raw herbs to synthetic pharmaceuticals bioactive compounds has undergone evolution and herbal medicine has become an important source of raw materials to treat different illnesses. Indeed, the alternative treatment using herbal medicine has come into demand in recent years and has renewed interest in the plants that are effective, safe, and culturally acceptable. In Morocco, several medicinal plants are used traditionally to treat kidney stones and in vitro and in vivo experimental studies have proved their antilithiasic activity. This review aims to list all in vitro and in vivo antilithiasic medicinal plants used by the Moroccan population and to present bioactive compounds responsible for this activity. Further, we determined some molecular targets by these bioactive compounds.


Keywords: Crystallization, Kidney stones, Phyto-molecules, Urinary.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309791667 and j.to_ip >=309791667 )) and ((j.from_date <= 1739835006 and j.to_date >= 1739835006 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14519) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309791667 and j.to_ip >=309791667 )) and ((j.from_date <= 1739835006 and j.to_date >= 1739835006 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14519) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309791667 and j.to_ip >=309791667 )) and ((j.from_date <= 1739835006 and j.to_date >= 1739835006 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 14519)
      690μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3033 and `b`.`banner_from_date` <= 1739835006 and `b`.`banner_to_date` >= 1739835006 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.18msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3033
      • 3: 1739835006
      • 4: 1739835006
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='9cfd6f55ad34c6b9d0693a1a25cdf8a6'
      270μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    4Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        qCYQSCbyYARjUcPKMWSGFiUhEV1bga8F5EqFch5n
        uc_cart_id
        9cfd6f55ad34c6b9d0693a1a25cdf8a6
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14519" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/14519
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IkFjS1lhMFU5bUV6MVdvOWs3UE1SVXc9PSIsInZhbHVlIjoiV2F2S2NjbENFQ1c2cmxEQ1QvUGJmb0dKTTJKcmwvWkgxWU05eHFVVE04VT0iLCJtYWMiOiJlMDRjZjM0NWViOTk3N2QzYjYyNzY1ODg3NzUwNGVkMmJjOWYyZWQyMjM5YzE0YzUyYzI5NzFhMzBmMmRjNDFlIiwidGFnIjoiIn0%3D; XSRF-TOKEN=eyJpdiI6IncxTU9JN1htQXltUFF2Q2JWRi9na1E9PSIsInZhbHVlIjoiR3RhZzNlUStyTThaVFpnNWVHWVhBeVJhRFVWK2YyaVdhbWJxYUsyOTgwNktOYzNvakllTW1PS002RWtDcGN5RElzNWd5SE1vcXg3NVE4ZVhJSTEzZDU5djdCV0I1NUhSTThjU2syZS9EZ2pFN1dLVDN5alltR0xMUVA3QkhxRy8iLCJtYWMiOiI5ZGVkYTk0YzhlMTQ4ZDc5Y2Y1ZDYzOTU1YzFmMDg2NzU0ZjE3YTcyMTBmZWJkZGNiYTQyY2ZlN2U0ZTc2ZTcyIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6ImR4azBTeDltL3h6UjJyVy93ZGNtRlE9PSIsInZhbHVlIjoidml6NFFZdVZNOW91aVBtWkJiZVZyYzB5NjNhZG0yaU5BNFl6Y2lBdUJCWDQzL25YNTVGdHlLQzVFelRFUmVZaUM3WjNvaGFxbDlWTkszN2lSeUl1Y1JQNW9oTnRhb1dVSDNnWmltRFZ3NnVaYWo4dktYdEdhRmpDOVVuRisxUUQiLCJtYWMiOiJiNTRmMzRiZjI2NjA0YzU4MGVjNmQ2YTdjZjU2Nzc1YjA1MmFiZDdmZWM1ZGRiMzRlYjc3ZTRkNzFiZjkwMzgwIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IkFjS1lhMFU5bUV6MVdvOWs3UE1SVXc9PSIsInZhbHVlIjoiV2F2S2NjbENFQ1c2cmxEQ1QvUGJmb0dKTTJKcmwvWkgxWU05eHFVVE04VT0iLCJtYWMiOiJlMDRjZjM0NWViOTk3" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        array:5 [ "_token" => "qCYQSCbyYARjUcPKMWSGFiUhEV1bga8F5EqFch5n" "uc_cart_id" => "9cfd6f55ad34c6b9d0693a1a25cdf8a6" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/14519" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:30:07GET/chapter/14519112196