摘要
背景：前驱阿尔茨海默病（AD）的诊断仍然是一个热门话题，人们对早期和非侵入性生物标志物的检测越来越感兴趣。尽管进行性情景记忆障碍是AD的典型主要特征，但是在疾病的早期阶段可能已经存在交流困难。目的：本研究探讨叙事语篇产生缺陷是CSF定义前驱AD的标志及其与脑低灌注模式的相关性。 方法：对28名患有轻度认知障碍（15 AD因AD; 13 MCI非AD）和28名健康对照的受试者进行叙事评估，采用多级程序进行语篇分析。诊断检查包括CSF AD生物标志物。通过SPECT图像处理鉴定脑灌注不足模式。 结果：结果表明，全球连贯性和词汇信息量指数的话语分析允许从MCI非AD和健康受试者中鉴定由AD引起的MCI。这些发现可以假设叙述疗效的丧失可能是阿尔茨海默病的早期临床标志。此外，在左额下回前部的背侧发现了全局连贯性和词汇信息量减少与SPECT低灌注的显着相关性，支持了这一区域在交际效能中具有重要作用的假设，特别是，在语义选择执行控制中。 结论：本研究有助于理解语言处理的神经网络及其对前驱阿尔茨海默病的影响。它还为临床实践提供了一种简单而灵敏的工具，可以帮助识别患有前驱性阿尔茨海默病的个体。
关键词: 轻度认知障碍，阿尔茨海默病，言语障碍，语言障碍，功能性神经影像学，词汇障碍。
[1]
Toepper M. Dissociating normal aging from Alzheimer’s disease: a view from cognitive neuroscience. J Alzheimers Dis 57(2): 331-52. (2017)
[2]
Kirshner HS. Primary progressive aphasia and Alzheimer’s disease: brief history, recent evidence. Curr Neurol Neurosci Rep 12(6): 709-14. (2012)
[3]
Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, et al. Revising the definition of Alzheimer's disease: a new lexicon, in Lancet Neurol. 2010, Copyright (c) 2010 Elsevier Ltd. All rights reserved.: England 1118-27.
[4]
Fraser KC, Meltzer JA, Rudzicz F. Linguistic features identify Alzheimer’s disease in narrative speech. J Alzheimers Dis 49(2): 407-22. (2016)
[5]
Faber-Langendoen K, Morris JC, Knesevich JW, LaBarge E, Miller JP, Berg L, et al. Aphasia in senile dementia of the Alzheimer type. Ann Neurol 23(4): 365-70. (1988)
[7]
Forbes-McKay KE, Venneri A. Detecting subtle spontaneous language decline in early Alzheimer’s disease with a picture description task. Neurol Sci 26(4): 243-54. (2005)
[8]
Oulhaj A, Wilcock GK, Smith AD, de Jager CA. Predicting the time of conversion to MCI in the elderly: role of verbal expression and learning. Neurology 73(18): 1436-42. (2009)
[9]
Lemos R, Afonso A, Martins C, Waters JH, Blanco FS, Simões MR, et al. Selective reminding and free and cued selective reminding in mild cognitive impairment and Alzheimer disease. Appl Neuropsychol Adult 23(2): 85-93. (2016)
[10]
Reilly JJ. Troche, Grossman, M. Language processing in dementia. The handbook of Alzheimer’s disease and other dementias, (2011); pp. p. 336-368.
[11]
Goedert M. NEURODEGENERATION. Alzheimer’s and Parkinson’s diseases: the prion concept in relation to assembled Abeta, tau, and alpha-synuclein. Science 349(6248)1255555 (2015)
[12]
Hane FT, Lee BY, Leonenko Z. Recent progress in Alzheimer’s disease research, Part 1: Pathology. J Alzheimers Dis 57(1): 1-28. (2017)
[13]
Taler V, Phillips NA. Language performance in Alzheimer’s disease and mild cognitive impairment: a comparative review. J Clin Exp Neuropsychol 30(5): 501-56. (2008)
[14]
Adlam A-LR, Bozeat S, Arnold R, Watson P, Hodges JR. Semantic knowledge in mild cognitive impairment and mild Alzheimer’s disease. Cortex 42(5): 675-84. (2006)
[15]
Salmon DP, Butters N, Chan AS. The deterioration of semantic memory in Alzheimer’s disease. Can J Exp Psychol 53(1): 108. (1999)
[16]
Marini A, Boewe A, Caltagirone C, Carlomagno S. Age-related differences in the production of textual descriptions. J Psycholinguist Res 34(5): 439-63. (2005)
[17]
Kavé G, Levy Y. Morphology in picture descriptions provided by persons with Alzheimer’s disease. J Speech Lang Hear Res 46(2): 341-52. (2003)
[18]
Nicholas M, Obler LK, Albert ML, Helm-Estabrooks N. Empty speech in Alzheimer’s disease and fluent aphasia. J Speech Hear Res 28(3): 405-10. (1985)
[19]
Marini A, Martelli S, Gagliardi C, Fabbro F. Narrative language in Williams Syndrome and its neuropsychological correlates. J Neurolinguist 23(2): 97-11. (2010)
[20]
Marini A, Andreetta S, del Tin S. Carlomagno Sergio. A multi-level approach to the analysis of narrative language in aphasia. Aphasiology 25(11): 1372-92. (2011)
[21]
Marini A, Galetto V, Zampieri E, Vorano L, Zettin M, Carlomagno S. Narrative language in traumatic brain injury. Neuropsychologia 49(10): 2904-10. (2011)
[22]
Carlomagno S, Santoro A, Menditti A, Pandolfi M, Marini A. Referential communication in Alzheimer’s type dementia. Cortex 41(4): 520-34. (2005)
[23]
Boschi V, Catricalà E, Consonni M, Chesi C, Moro A, Cappa SF. Connected speech in neurodegenerative language disorders: a review. Front Psychol 8: 269. (2017)
[24]
Drummond C, Coutinho G, Fonseca RP, Assunção N, Teldeschi A, de Oliveira-Souza R, et al. Deficits in narrative discourse elicited by visual stimuli are already present in patients with mild cognitive impairment. Front Aging Neurosci 7: 96. (2015)
[25]
Ahmed S, Haigh AM, de Jager CA, Garrard P. Connected speech as a marker of disease progression in autopsy-proven Alzheimer’s disease. Brain 136(Pt 12): 3727-37. (2013)
[26]
Cuetos F, Arango-Lasprilla JC, Uribe C, Valencia C, Lopera F. Linguistic changes in verbal expression: a preclinical marker of Alzheimer’s disease. J Int Neuropsychol Soc 13(3): 433-9. (2007)
[27]
Spalletta G, Spoletini I, Cherubini A, Rubino IA, Siracusano A, Piras F, et al. Cortico-subcortical underpinnings of narrative processing impairment in schizophrenia. Psychiatry Res 182(1): 77-80. (2010)
[28]
Blank SC, Scott SK, Murphy K, Warburton E, Wise RJ. Speech production: wernicke, Broca and beyond. Brain 125(Pt 8): 1829-38. (2002)
[29]
Blank SC, Bird H, Turkheimer F, Wise RJ. Speech production after stroke: the role of the right pars opercularis. Ann Neurol 54(3): 310-20. (2003)
[30]
Marini A, Urgesi C. Please get to the point! A cortical correlate of linguistic informativeness. J Cogn Neurosci 24(11): 2211-22. (2012)
[31]
Vigneau M, Beaucousin V, Hervé PY, Duffau H, Crivello F, Houdé O, et al. Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing. Neuroimage 30(4): 1414-32. (2006)
[32]
Wagner AD, Paré-Blagoev EJ, Clark J, Poldrack RA. Recovering meaning: left prefrontal cortex guides controlled semantic retrieval. Neuron 31(2): 329-38. (2001)
[33]
Whitney C, Kirk M, O’Sullivan J, Lambon Ralph MA, Jefferies E. The neural organization of semantic control: TMS evidence for a distributed network in left inferior frontal and posterior middle temporal gyrus. Cereb Cortex 21(5): 1066-75. (2011)
[34]
Whitney C, Kirk M, O’Sullivan J, Lambon Ralph MA, Jefferies E. Executive semantic processing is underpinned by a large-scale neural network: revealing the contribution of left prefrontal, posterior temporal, and parietal cortex to controlled retrieval and selection using TMS. J Cogn Neurosci 24(1): 133-47. (2012)
[35]
Badre D, Poldrack RA, Paré-Blagoev EJ, Insler RZ, Wagner AD. Dissociable controlled retrieval and generalized selection mechanisms in ventrolateral prefrontal cortex. Neuron 47(6): 907-18. (2005)
[36]
Badre D, Wagner AD. Left ventrolateral prefrontal cortex and the cognitive control of memory. Neuropsychologia 45(13): 2883-901. (2007)
[37]
Mueller KD, Koscik RL, Turkstra LS, Riedeman SK, LaRue A, Clark LR, et al. Connected language in late middle-aged adults at risk for Alzheimer’s disease. J Alzheimers Dis 54(4): 1539-50. (2016)
[38]
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3): 189-98. (1975)
[39]
Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4): 695-9. (2005)
[40]
Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 256(3): 183-94. (2004)
[41]
Petersen RC, Caracciolo B, Brayne C, Gauthier S, Jelic V, Fratiglioni L. Mild cognitive impairment: a concept in evolution. J Intern Med 275(3): 214-28. (2014)
[42]
Matthews FE. Two Year Progression from mild cognitive impairment to dementia: to what extent do different definitions agree? J Am Geriatr Soc 56(8): 1424-33. (2008)
[43]
Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43(11): 2412-4. (1993)
[45]
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3): 263-9. (2011)
[46]
Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3): 270-9. (2011)
[47]
Dubois B, Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol 13(6): 614-29. (2014)
[48]
Blennow K, Hampel H, Weiner M, Zetterberg H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 6(3): 131-44. (2010)
[49]
Mulder C, Verwey NA, van der Flier WM, Bouwman FH, Kok A, van Elk EJ, et al. Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clin Chem 56(2): 248-53. (2010)
[50]
van Harten AC, Visser PJ, Pijnenburg YA, Teunissen CE, Blankenstein MA, Scheltens P, et al. Cerebrospinal fluid Abeta42 is the best predictor of clinical progression in patients with subjective complaints. Alzheimers Dement 9(5): 481-7. (2013)
[51]
Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L. Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 5(3): 228-34. (2006)
[52]
Duits FH, Teunissen CE, Bouwman FH, Visser PJ, Mattsson N, Zetterberg H, et al. The cerebrospinal fluid “Alzheimer profile”: easily said, but what does it mean? Alzheimers Dement 10(6): 713-723.e2. (2014)
[53]
Monaco M, Costa A, Caltagirone C, Carlesimo GA. Forward and backward span for verbal and visuo-spatial data: standardization and normative data from an Italian adult population. Neurol Sci 34(5): 749-54. (2013)
[54]
Mauri M. Standardizzazione di due nuovi test di memoria: apprendimento di liste di parole correlate e non correlate semanticamente. Arch Psicol Neurol Psichiatr 5-6: 621-45. (1997)
[55]
Spinnler H, Tognoni G. Standardizzazione e taratura italiana di test neuropsicologici 1987 Masson Italia Periodici.
[56]
Caffarra P, Vezzadini G, Dieci F, Zonato F, Venneri A. Rey-Osterrieth complex figure: normative values in an Italian population sample. Neurol Sci 22(6): 443-7. (2002)
[57]
Giovagnoli AR, Del Pesce M, Mascheroni S, Simoncelli M, Laiacona M, Capitani E, et al. Trail making test: normative values from 287 normal adult controls. Ital J Neurol Sci 17(4): 305-9. (1996)
[58]
Brugnolo A, De Carli F, Accardo J, Amore M, Bosia LE, Bruzzaniti C, et al. An updated Italian normative dataset for the Stroop color word test (SCWT). Neurol Sci 37(3): 365-72. (2016)
[59]
Caffarra P, Vezzadini G, Dieci F, Zonato F, Venneri A. Modified card sorting test: normative data. J Clin Exp Neuropsychol 26(2): 246-50. (2004)
[60]
Della Sala S, MacPherson SE, Phillips LH, Sacco L, Spinnler H. How many camels are there in Italy? Cognitive estimates standardised on the Italian population. Neurol Sci 24(1): 10-5. (2003)
[61]
Scarpina F, D’Aniello GE, Mauro A, Castelnuovo G, MacPherson SE. How many segments are there in an orange: normative data for the new Cognitive Estimation Task in an Italian population. Neurol Sci 36(10): 1889-95. (2015)
[62]
Novelli G, Papagno C, Capitani E, Laiacona M. Tre test clinici di memoria verbale a lungo termine: taratura su soggetti normali. / Three clinical tests for the assessment of verbal long-term memory function: norms from 320 normal subjects. Arch Psicol Neurol Psichiatr 47(2): 278-96. (1986)
[63]
Costa A, Bagoj E, Monaco M, Zabberoni S, De Rosa S, Papantonio AM, et al. Standardization and normative data obtained in the Italian population for a new verbal fluency instrument, the phonemic/semantic alternate fluency test. Neurol Sci 35(3): 365-72. (2014)
[64]
Luzzatti C, Willmes K, De Bleser R. Aachener aphasie test: versione italiana. (1996) Organizzazioni Speciali: Firenze
[65]
Catricala E, Della Rosa PA, Ginex V, Mussetti Z, Plebani V, Cappa SF. An Italian battery for the assessment of semantic memory disorders. Neurol Sci 34(6): 985-93. (2013)
[66]
Goodglass H, Kaplan E. The Boston Diagnostic Aphasia Examination. (1972) Philadelphia Lea & Febiger
[68]
Huber W, Gleber J. Linguistic and nonlinguistic processing of narratives in aphasia. Brain Lang 16(1): 1-18. (1982)
[69]
Andreetta S, Marini A. The effect of lexical deficits on narrative disturbances in fluent aphasia. Aphasiology 29(6): 705-23. (2015)
[70]
Matsuda H, Mizumura S, Nagao T, Ota T, Iizuka T, Nemoto K, et al. Automated discrimination between very early Alzheimer disease and controls using an easy Z-score imaging system for multicenter brain perfusion single-photon emission tomography. Am J Neuroradiol 28(4): 731-6. (2007)
[71]
Waragai M, Yamada T, Matsuda H. Evaluation of brain perfusion SPECT using an easy Z-score imaging system (eZIS) as an adjunct to early-diagnosis of neurodegenerative diseases. J Neurol Sci 260(1-2): 57-64. (2007)
[72]
de Lira JO, Ortiz KZ, Campanha AC, Bertolucci PH, Minett TS. Microlinguistic aspects of the oral narrative in patients with Alzheimer’s disease. Int Psychogeriatr 23(03): 404-12. (2011)
[73]
Hoffmann I, Nemeth D, Dye CD, Pákáski M, Irinyi T, Kálmán J. Temporal parameters of spontaneous speech in Alzheimer’s disease. Int J Speech Lang Pathol 12(1): 29-34. (2010)
[74]
Sajjadi SA, Patterson K, Tomek M, Nestor PJ. Abnormalities of connected speech in semantic dementia vs Alzheimer’s disease. Aphasiology 26(6): 847-66. (2012)
[75]
Lai Y-H. Discourse features of chinese-speaking seniors with and without Alzheimer’s disease. Lang Linguis 15(3): 411-34. (2014)
[76]
Cannizzaro MS, Dumas J, Prelock P, Newhouse P. Organizational structure reduces processing load in the prefrontal cortex during discourse processing of written text: implications for high-level reading issues after TBI. Perspect Neurophysiol Neurogenic Speech Lang Disord 22(2): 67-78. (2012)
[77]
Laws KR, Duncan A, Gale TM. ‘Normal’ semantic-phonemic fluency discrepancy in Alzheimer’s disease? A meta-analytic study. Cortex 46(5): 595-601. (2010)
[78]
Hodges JR, Salmon DP, Butters N. Semantic memory impairment in Alzheimer’s disease: failure of access or degraded knowledge? Neuropsychologia 30(4): 301-14. (1992)
[79]
Caselli RJ, Locke DE, Dueck AC, Knopman DS, Woodruff BK, Hoffman-Snyder C, et al. The neuropsychology of normal aging and preclinical Alzheimer's disease. Alzheimers Dement 2014; 10(1): 84-92. (2014)
[80]
Indefrey P, Levelt WJM. The neural correlates of language production. inThe new cognitive neurosciences 2nd ed 2000, MIT press p. 845-65.
[81]
Jefferies E, Ralph L, Matthew A. Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison. Brain 129(8): 2132-47. (2006)
[82]
Jefferies E, Patterson K, Ralph MA. Deficits of knowledge versus executive control in semantic cognition: insights from cued naming. Neuropsychologia 46(2): 649-58. (2008)
[83]
Novick JM, Kan IP, Trueswell JC, Thompson-Schill SL. A case for conflict across multiple domains: memory and language impairments following damage to ventrolateral prefrontal cortex. Cogn Neuropsychol 26(6): 527-67. (2009)
Related Books
Frontiers in Clinical Drug Research - CNS and Neurological Disorders
Frontiers in Clinical Drug Research - CNS and Neurological Disorders
Frontiers in Clinical Drug Research - CNS and Neurological Disorders
Frontiers in Clinical Drug Research-Dementia
Frontiers in Clinical Drug Research - CNS and Neurological Disorders
Article Metrics
57
2