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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Research Article

Emergence of Heteroresistance Mycobacterium Tuberculosis in Saudi Arabia

Author(s): Eltayib H. Ahmed Abakur, Tarig M.S. Alnour*, Faisel Abuduhier, Fahad M.A. Albalawi and Khalid A.S. Alfifi

Volume 20, Issue 4, 2020

Page: [491 - 494] Pages: 4

DOI: 10.2174/1871526519666190326141550

Price: $65

Abstract

Purpose: Heteroresistant Mycobacterium tuberculosis (MTB) is defined as a group of drug-susceptible and resistant bacteria in a single clinical specimen from tuberculosis (TB) patients. Heteroresistance of MTB is considered a preliminary stage to full resistance. The present study aimed to determine the heteroresistance in Mycobacterium tuberculosis in Tabuk province, in the north of the Kingdom of Saudi Arabia.

Method: GenoType MTBDRplus assay was used to determine mutations associated with isoniazid and rifampicin resistance.

Results: A total number of 46 confirmed M. tuberculosis positive sputum samples were scanned for heteroresistance. The present study revealed 3 (6.5%) heteroresistant mutations to either rpoB gene alone, 2 (4.4%) to rpoB and 1 (2.2%) to inhA genes.

Conclusion: The detection of heteroresistant mutations could guide the initiation of an appropriate regimen of treatment.

Keywords: Heteroresistance, Mycobacterium tuberculosis, drug resistance, rpoB mutation, inhA mutation, Tuberculosis (TB).

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