Abstract
Medicinal chemistry is intimately connected with basic science such as organic synthesis, chemical biology and biophysical chemistry among other disciplines. The reason of such connections is due to the power of organic synthesis to provide designed molecules; chemical biology to give tools to discover biological and/or pathological pathways and biophysical chemistry which provides the techniques to characterize and the theoretical background to understand molecular behaviour. The present review provides some selective examples of these research areas. Initially, template dsDNA organic synthesis and the spatio-temporal control of transcription are presenting following by the supramolecular entities used in drug delivery, such as liposomes and liquid crystal among others. Finally, peptides and protein self-assembly is connected with biomaterials and as an important event in the balance between health and disease. The final aim of the present review is to show the power of chemical tools not only for the synthesis of new molecules but also to improve our understanding of recognition and self-assembly in the biological context.
Keywords: Biomimetic, conformational diseases, drug delivery, molecular triggers, peptides, protein unfolding, smart vesicles, supramolecular systems.
Current Topics in Medicinal Chemistry
Title:Understanding Recognition and Self-assembly in Biology using the Chemist´s Toolbox. Insight into Medicinal Chemistry
Volume: 14 Issue: 6
Author(s): Z.B. Quirolo, L.A. Benedini, M.A. Sequeira, M.G. Herrera, T.V. Veuthey and V.I. Dodero
Affiliation:
Keywords: Biomimetic, conformational diseases, drug delivery, molecular triggers, peptides, protein unfolding, smart vesicles, supramolecular systems.
Abstract: Medicinal chemistry is intimately connected with basic science such as organic synthesis, chemical biology and biophysical chemistry among other disciplines. The reason of such connections is due to the power of organic synthesis to provide designed molecules; chemical biology to give tools to discover biological and/or pathological pathways and biophysical chemistry which provides the techniques to characterize and the theoretical background to understand molecular behaviour. The present review provides some selective examples of these research areas. Initially, template dsDNA organic synthesis and the spatio-temporal control of transcription are presenting following by the supramolecular entities used in drug delivery, such as liposomes and liquid crystal among others. Finally, peptides and protein self-assembly is connected with biomaterials and as an important event in the balance between health and disease. The final aim of the present review is to show the power of chemical tools not only for the synthesis of new molecules but also to improve our understanding of recognition and self-assembly in the biological context.
Export Options
About this article
Cite this article as:
Quirolo Z.B., Benedini L.A., Sequeira M.A., Herrera M.G., Veuthey T.V. and Dodero V.I., Understanding Recognition and Self-assembly in Biology using the Chemist´s Toolbox. Insight into Medicinal Chemistry, Current Topics in Medicinal Chemistry 2014; 14 (6) . https://dx.doi.org/10.2174/1568026614666140118220825
DOI https://dx.doi.org/10.2174/1568026614666140118220825 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of Rap2 and its Downstream Effectors in Tumorigenesis
Anti-Cancer Agents in Medicinal Chemistry Anti-carcinogenic Effect of Cathepsin K Inhibitor, Odanacatib with a Low Dose of Cisplatin Against Human Breast Carcinoma MCF-7 and MDA-MB231 Cells
Current Cancer Therapy Reviews Overview of the Molecular Bases of Resistance to Chemotherapy in Liver and Gastrointestinal Tumours
Current Molecular Medicine From Systems Biology to Systems Pathology: A New Subspecialty in Diagnostic and Personalized Medicine
Current Pharmacogenomics and Personalized Medicine Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy
Mini-Reviews in Medicinal Chemistry Emulsomes Meet S-layer Proteins: An Emerging Targeted Drug Delivery System
Current Pharmaceutical Biotechnology The Genetic Basis of New Treatment Modalities in Melanoma
Current Drug Targets Adjuvant Hormonal Therapy in Women with Early-stage Breast Cancer
Medicinal Chemistry The Role of PGC-1α in Digestive System Malignant Tumours
Anti-Cancer Agents in Medicinal Chemistry Editorial (Thematic Issue: Polymers in Drug Delivery)
Current Pharmaceutical Design Antisense Strategies in Therapy of Gliomas
Current Signal Transduction Therapy PPAR-Gamma in Ulcerative Colitis: A Novel Target for Intervention
Current Drug Targets Polypharmacological Properties and Therapeutic Potential of β-Caryophyllene: A Dietary Phytocannabinoid of Pharmaceutical Promise
Current Pharmaceutical Design Improvement of Adoptive Cellular Immunotherapy of Human Cancer Using Ex-Vivo Gene Transfer
Current Gene Therapy Survivin as a Prognostic/Predictive Marker and Molecular Target in Cancer Therapy
Current Medicinal Chemistry Metallothioneins and Cancer
Current Protein & Peptide Science Exploring the Management of Statin Intolerant Patients: 2016 and Beyond
Current Vascular Pharmacology Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective
Current Pharmaceutical Design Vitamin D Supplementation and Cancer: Review of Randomized Controlled Trials
Anti-Cancer Agents in Medicinal Chemistry Cardiovascular Risk Calculators and their Applicability to South Asians
Current Diabetes Reviews