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Review Article

富含甘油三酯的脂蛋白作为动脉壁促炎脂质的来源

卷 26, 期 9, 2019

页: [1701 - 1710] 页: 10

弟呕挨: 10.2174/0929867325666180530094819

价格: $65

摘要

载脂蛋白B-含脂蛋白包括富含甘油三酯的脂蛋白（乳糜微粒及其残余物，以及极低密度脂蛋白及其残余物）和富含胆固醇的低密度脂蛋白颗粒。其中，大小在70-80nm以下的脂蛋白可进入动脉壁，在动脉壁积聚并诱导动脉粥样硬化病变的形成。导致脂蛋白源性脂质在动脉壁中积聚的过程在很大程度上被研究，重点是低密度脂蛋白颗粒。然而，最近的观察和遗传学研究发现，富含甘油三酯的脂蛋白及其残余物与心血管疾病风险有关。在这篇综述中，我们描述了富含甘油三酯的残余脂蛋白有助于动脉粥样硬化病变发展的潜在机制，并强调了低密度脂蛋白和残余脂蛋白之间动脉粥样硬化的差异。

关键词: 乳糜微粒、VLDL、残余物、甘油三酯、胆固醇、动脉粥样硬化、炎症。

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