The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death

Title: The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death

Volume: 10 Issue: 16

Author(s): David J. Granville and Roberta A. Gottlieb

Affiliation:

Keywords: mitochondria, apoptosis, vdac, heart, cytochrome c, cell death

Abstract: Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.

Cite this article as:

Granville J. David and Gottlieb A. Roberta, The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death, Current Medicinal Chemistry 2003; 10 (16) . https://dx.doi.org/10.2174/0929867033457214