Abstract
Postmenopausal women make up one of the fastest growing populations in the United States. Women typically have a higher incidence of cardiovascular disease following menopause. One of the major risk factors for cardiovascular disease is hypertension, and after menopause, blood pressure (BP) increases progressively in women. Also after menopause, the progression of renal disease increases in women compared with aged matched men. However, the mechanism( s) responsible for the post-menopausal increase in BP and renal injury are yet to be elucidated. Moreover the best therapeutic options to treat postmenopausal hypertension in women are not clear. Hypertension in postmenopausal women are usually associated with other cardiovascular risk factors, such as dyslipidemias, visceral obesity and endothelial dysfunction. Recently it became apparent that in a large number of hypertensive postmenopausal women, their BP is not well controlled with conventional antihypertensive medications. A clear understanding of the complex pathogenesis of postmenopausal hypertension is needed in order to offer the best therapeutic options for these women.
Keywords: dyslipidemias, cardiovascular risk factors, renal disease, hypertension, cardiovascular disease, visceral obesity, sex steroids sympathetic, menopause, endothelin, blood pressure, angiotensin II, Aldosterone
Current Topics in Medicinal Chemistry
Title: A Single Pill to Treat Postmenopausal Hypertension? Not Yet
Volume: 11 Issue: 13
Author(s): Jane F. Reckelhoff, Radu Iliescu, Damian G. Romero and Licy L. Yanes
Affiliation:
Keywords: dyslipidemias, cardiovascular risk factors, renal disease, hypertension, cardiovascular disease, visceral obesity, sex steroids sympathetic, menopause, endothelin, blood pressure, angiotensin II, Aldosterone
Abstract: Postmenopausal women make up one of the fastest growing populations in the United States. Women typically have a higher incidence of cardiovascular disease following menopause. One of the major risk factors for cardiovascular disease is hypertension, and after menopause, blood pressure (BP) increases progressively in women. Also after menopause, the progression of renal disease increases in women compared with aged matched men. However, the mechanism( s) responsible for the post-menopausal increase in BP and renal injury are yet to be elucidated. Moreover the best therapeutic options to treat postmenopausal hypertension in women are not clear. Hypertension in postmenopausal women are usually associated with other cardiovascular risk factors, such as dyslipidemias, visceral obesity and endothelial dysfunction. Recently it became apparent that in a large number of hypertensive postmenopausal women, their BP is not well controlled with conventional antihypertensive medications. A clear understanding of the complex pathogenesis of postmenopausal hypertension is needed in order to offer the best therapeutic options for these women.
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F. Reckelhoff Jane, Iliescu Radu, G. Romero Damian and L. Yanes Licy, A Single Pill to Treat Postmenopausal Hypertension? Not Yet, Current Topics in Medicinal Chemistry 2011; 11 (13) . https://dx.doi.org/10.2174/156802611796117667
DOI https://dx.doi.org/10.2174/156802611796117667 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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