Mitochondrial Dysfunction and Oxidative Stress in Insulin Resistance

Title:Mitochondrial Dysfunction and Oxidative Stress in Insulin Resistance

Volume: 19 Issue: 32

Author(s): Milagros Rocha, Susana Rovira-Llopis, Celia Banuls, Lorena Bellod, Rosa Falcon, Raquel Castello, Carlos Morillas, Jose R. Herance, Antonio Hernandez-Mijares and Victor M. Victor

Affiliation:

Keywords: Insulin resistance, mitochondria, oxidative stress, antioxidants.

Abstract: Evidence is mounting of the involvement of mitochondrial dysfunction in insulin resistance, diabetes and associated complications. This review aims to provide an overview of the effects of insulin resistance on mitochondrial function in several tissues. We consider the pathogenesis of insulin resistance from a mitochondrial perspective and contemplate potential beneficial effects of strategies aimed at modulating mitochondrial function in insulin resistance, including insulin and insulin-sensitizing drugs, antioxidants, and selectively targeting antioxidants to mitochondria.

Cite this article as:

Rocha Milagros, Rovira-Llopis Susana, Banuls Celia, Bellod Lorena, Falcon Rosa, Castello Raquel, Morillas Carlos, Herance R. Jose, Hernandez-Mijares Antonio and Victor M. Victor, Mitochondrial Dysfunction and Oxidative Stress in Insulin Resistance, Current Pharmaceutical Design 2013; 19 (32) . https://dx.doi.org/10.2174/13816128113199990373