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General Review Article

褪黑素作为预防癌症中的活性药理分子的见解：新功能？

卷 26, 期 34, 2019

页: [6304 - 6320] 页: 17

弟呕挨: 10.2174/0929867325666180501094850

价格: $65

摘要

褪黑素除了在昼夜节律中起重要作用外，还被认为在防止细胞受损，抑制生长和触发恶性细胞凋亡中起重要作用。它与昼夜节律，精力旺盛的动态平衡，饮食和新陈代谢的关系，对于更好地理解褪黑素如何被视为化学预防分子至关重要，尽管涉及此问题的论文很少。在本文中，我们试图回顾有关褪黑素与饮食和代谢平衡有关的保护和抗肿瘤机制的最新证据。从不同的研究中，很明显，在高剂量褪黑素存在于恶性细胞中时，通过上调抗氧化剂基因电池来激活细胞内抗氧化剂防御机制。像其他广谱抗氧化剂分子一样，褪黑激素在杀死肿瘤细胞，预防转移以及同时保护正常细胞免受氧化应激和其他类型的组织损伤方面起着至关重要的作用。

关键词: 褪黑素，抗氧化剂，细胞凋亡，乳腺癌，转移，氧化应激。

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