The Development of Pro-Apoptotic Cancer Therapeutics

Title: The Development of Pro-Apoptotic Cancer Therapeutics

Volume: 8 Issue: 7

Author(s): Noha I. Ziedan, Hachemi Kadri and Andrew D. Westwell

Affiliation:

Keywords: Pro-apoptotic cancer therapy, selective antitumour agents, apoptosis, small molecules, mitochondria-targeting, Xlinked inhibitor of apoptosis (XIAP), B-cell lymphoma 2 (Bcl-2), aerobic glycolysis

Abstract: Resistance to apoptosis is one of the fundamental hallmarks of cancer. Recently, the selective induction of apoptosis in cancer cells has emerged as an exciting possibility for the development of future selective cancer therapy. This review will summarise the development of the major classes of small molecule “pro-apoptotic” antitumour agents.

Cite this article as:

Ziedan I. Noha, Kadri Hachemi and Westwell D. Andrew, The Development of Pro-Apoptotic Cancer Therapeutics, Mini-Reviews in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/138955708784567430