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Review Article

佛手柑精油对疼痛相关BPSDs的临床管理的神经药理学特性

卷 26, 期 20, 2019

页: [3764 - 3774] 页: 11

弟呕挨: 10.2174/0929867325666180307115546

价格: $65

摘要

背景：阿尔茨海默氏病（AD）约占所有痴呆病例的50％，尽管在开发可改善疾病的药物方面做出了巨大努力，但尚无明确的认知障碍治疗方法。为了更好地控制该疾病，需要完全坚持目前的认知能力下降疗法，这已被证明可以减少（尽管不能完全消除）痴呆症的相关行为和心理症状（BPSD）的发生。这些症状明显影响患者的健康相关生活质量（HRQL），与疼痛状态密切相关。抗精神病药是治疗BPSD的唯一方法。但是，这些药物在短期内（6-12周）更有效，更安全，能够控制攻击性但不能控制躁动，并且无法控制疼痛。 Melissa officinalis和Lavandula officinalis的香薰疗法已被用于处理BPSD，但尚未提供强有力的证据来减轻疼痛。 目的：佛手柑精油（BEO）通过多种药理机制发挥抗伤害作用：特别是，它能够增强自噬，而自噬是在慢性疼痛中发生紊乱的过程。因此，已经指出了在BPSD的治疗中用BEO进行芳香疗法的临床翻译的良好药理基础。 结论：BEO在实验性疼痛模型中引起的抗伤害感受力使其成为与疼痛相关的BPSD的药理学治疗的可能候选者。

关键词: 香薰，佛手柑精油，老年痴呆症，痴呆症，痴呆症的行为和心理症状，疼痛。

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