Abstract
Glycaemic management is of paramount importance in the cardiac surgery setting. A growing body of evidence confirms a J-shaped relationship between blood glucose (BG) level and perioperative morbidity and mortality. On one hand, acute hypoglycaemia causes irreversible cerebral damage. On the other hand, hyperglycaemia increases the risk of infections, acute kidney injury, atrial fibrillation, low cardiac output syndrome, cerebrovascular accidents and cognitive impairment. Also, high BG variability, even within the therapeutic window, may deteriorate the outcome. Therefore, moderate perioperative insulin management is usually recommended, with target BG adjusted to individual needs and possibilities. Continuous BG monitoring is a promising tool that should help practitioners in everyday decision-making process of glycaemic control.
This review summarises the current evidence-based knowledge on the perioperative management of hyperglycaemia.
Keywords: Blood glucose, cardiac surgery, insulin therapy, perioperative period.
Current Vascular Pharmacology
Title:Glycaemic Control in Cardiac Surgery Patients: a Double-Edged Sword
Volume: 13 Issue: 5
Author(s): Lukasz J. Krzych and Maciej T. Wybraniec
Affiliation:
Keywords: Blood glucose, cardiac surgery, insulin therapy, perioperative period.
Abstract: Glycaemic management is of paramount importance in the cardiac surgery setting. A growing body of evidence confirms a J-shaped relationship between blood glucose (BG) level and perioperative morbidity and mortality. On one hand, acute hypoglycaemia causes irreversible cerebral damage. On the other hand, hyperglycaemia increases the risk of infections, acute kidney injury, atrial fibrillation, low cardiac output syndrome, cerebrovascular accidents and cognitive impairment. Also, high BG variability, even within the therapeutic window, may deteriorate the outcome. Therefore, moderate perioperative insulin management is usually recommended, with target BG adjusted to individual needs and possibilities. Continuous BG monitoring is a promising tool that should help practitioners in everyday decision-making process of glycaemic control.
This review summarises the current evidence-based knowledge on the perioperative management of hyperglycaemia.
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Cite this article as:
Krzych J. Lukasz and Wybraniec T. Maciej, Glycaemic Control in Cardiac Surgery Patients: a Double-Edged Sword, Current Vascular Pharmacology 2015; 13 (5) . https://dx.doi.org/10.2174/1570161112666140224145707
DOI https://dx.doi.org/10.2174/1570161112666140224145707 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
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