The Effects of Genetic Polymorphism on Treatment Response of Recombinant Human Growth Hormone

Title:The Effects of Genetic Polymorphism on Treatment Response of Recombinant Human Growth Hormone

Volume: 19 Issue: 14

Author(s): Shi Chen, Hanxiao You, Hui Pan*, Huijuan Zhu, Hongbo Yang, Fengying Gong, Linjie Wang, Yu Jiang and Chengsheng Yan

Affiliation:

• Department of Endocrinology, Key Lab of Endocrinology, Ministry of Health, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing,China

Keywords: Insulin-like growth factor 1, rhGH, growth hormone treatment, genetic polymorphisms, pharmacogenomics, pharmacodynamics.

Abstract: Background: Recombinant human growth hormone (rhGH) has been widely used in clinical treatment and technology has achieved a great development in different long-acting formulations. Genetic polymorphisms may play a role in the varies of individual responses in treatment process. This article gives an overview of the genetic polymorphisms research of growth hormone in recent years.

Methods: We conducted a scoping literature search of PubMed for all English-language publications to identify studies on recombinant human growth hormone and genetic polymorphism from 2000 to 2016. Included studies were all peer-reviewed primary journal articles. Two authors independently screened titles/abstracts, downloading full-text publications meeting inclusion criteria.

Results: In all, 96 studies were included and analyzed. We found that besides some well known factors ,such as races, age, gender, weight, several kinds of gene polymorphism reported ever can also affect the growth hormone response in GHD or non-GHD patients, including GHR-Exon 3, IGF(CA)19, IGFBP-3, APOB, CETP, SOCS2, VDR, LEPR and STAT5B.

Conclusion: Serum IGF-1 is a good parameter of GH treatment response. But it is influenced by various factors, including races, age, gender, weight, initial IGF-1 level, injection concentration and frequency. Gene polymorphism research has been a research hopspot in recent years, may helping understand the pathogeny and pharmacogenomics of these response varieties during GH treatment.

Cite this article as:

Chen Shi , You Hanxiao, Pan Hui *, Zhu Huijuan , Yang Hongbo , Gong Fengying , Wang Linjie, Jiang Yu and Yan Chengsheng, The Effects of Genetic Polymorphism on Treatment Response of Recombinant Human Growth Hormone, Current Drug Metabolism 2018; 19 (14) . https://dx.doi.org/10.2174/1389200219666171207115403