Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin

Title: Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin

Volume: 16 Issue: 1

Author(s): Shakil A. Khan and Fahim H. Khan

Affiliation:

Keywords: Caprine, alpha-2-macroglobulin, hydroxyl radical

Abstract: ROS, including .OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2 .- and H2O2/HOCl are physiologically relevant inactivators of α2M, a key anti-proteinase. Here, we show that .OH disrupted caprine α2M structure and antiproteolytic potential in vitro, suggesting that its function could be compromised via oxidative modification.

Cite this article as:

Khan A. Shakil and Khan H. Fahim, Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin, Protein & Peptide Letters 2009; 16 (1) . https://dx.doi.org/10.2174/092986609787049376