摘要
我们小组最近开发了一类新的肽模拟物，称为“γ-AApeptides”。与其他肽模拟物类似，γ-AA肽对蛋白水解降解具有抗性，并且具有引入化学上不同的官能团的无限潜力。 γ-AA肽在生物医学应用中显示出巨大的希望。在本文中，我们将回顾几个具有生物学潜力的γ-AA肽的例子。某些γ-AA肽可以渗透细胞膜，因此它们可以用作潜在的药物载体。 γ-AA肽也可以高特异性和亲和力结合HIV RNA，表明它们可能作为抗HIV药物应用。此外，它们可以模拟宿主防御肽并显示出对一系列耐药细菌病原体的有效和广谱活性。它们也是潜在的抗癌剂。例如，它们在小鼠模型中对肿瘤的靶向成像显示出巨大的希望，并且它们还能够破坏p53 / DNA相互作用，从而拮抗STAT3信号传导途径。最近，通过组合筛选，鉴定出γ-AA肽抑制Aβ肽聚集，因此它们可以发展成潜在的抗阿尔茨海默病病原体。
关键词: γ-AA肽，肽模拟物，结构，抗癌活性，抗微生物活性，抗HIV活性，抗Aβ聚集。
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