A Computational View of COX-2 Inhibition

Title: A Computational View of COX-2 Inhibition

Volume: 6 Issue: 3

Author(s): Philippe Chavatte and Amaury Farce

Affiliation:

Keywords: COX-1 enzyme, Diarylheterocycles, COX-2 isoenzymes, nimesulide, QSAR studies, Neural Networks

Abstract: Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.

Cite this article as:

Chavatte Philippe and Farce Amaury, A Computational View of COX-2 Inhibition, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/187152006776930909