Dual Nuclear/Fluorescence Imaging Potantial of Zinc(II) Phthalocyanine in MIA PaCa-2 Cell Line

Title:Dual Nuclear/Fluorescence Imaging Potantial of Zinc(II) Phthalocyanine in MIA PaCa-2 Cell Line

Volume: 9 Issue: 3

Author(s): Fatma Yurt Lambrecht, Mine Ince, Ozge Er, Kasim Ocakoglu, Fatma Aslıhan Sarı, Cagla Kayabasi and Cumhur Gunduz

Affiliation:

Keywords: ¹³¹I, fluorescence imaging, nuclear imaging, MRI, Pancreatic cancer, Zinc(II) Phthalocyanine.

Abstract: Background and Objective: Pancreatic cancer is very common and difficult to diagnose in early stage. Imaging systems for diagnosing cancer have many disadvantages. However, combining different imaging modalities offers synergistic advantages. Optical imaging is the most multidirectional and widely used imaging modality in both clinical practice and research.

Methods: In present study, Zinc(II) phthalocyanine [Zn(II)Pc] was synthesized, labeled with iodine- 131 and in vitro study was carried out. The intracellular uptake studies of radiolabeled Zn(II)Pc were performed in WI-38 [ATCC CCL-75™, tissue: human fibroblast lung] and MIA PaCa-2 [ATCC CRL-1420™, tissue: human epithelial pancreas carcinoma] cell lines.

Results: The intracellular uptake efficiency of radiolabeled Zn(II)Pc in MIA PaCa-2 cells was determined two times higher than WI-38 cells. Also, fluorescence imaging (FI) efficiency of synthesized Zn(II)Pc was investigated in MIA PaCa-2 cells and significant uptake was observed.

Conclusion: Zn(II)Pc might be used as a new agent for dual fluorescence/nuclear imaging for pancreatic cancer.

Cite this article as:

Lambrecht Yurt Fatma, Ince Mine, Er Ozge, Ocakoglu Kasim, Sarı Aslıhan Fatma, Kayabasi Cagla and Gunduz Cumhur, Dual Nuclear/Fluorescence Imaging Potantial of Zinc(II) Phthalocyanine in MIA PaCa-2 Cell Line, Current Radiopharmaceuticals 2016; 9 (3) . https://dx.doi.org/10.2174/1874471009666160628083416