摘要
基因组研究的发展使乳腺癌的基因和分子分析成为可能，也揭示出这种疾病深度的复杂性和特异性。乳腺癌亚型特征，以突变为特征，某些原癌基因扩增与复发和预后不良率增加有关。这表明只有有限的药物来治疗它。如今，代谢重组被明确地确立为癌症的标志。肿瘤组织中脂质和蛋白质合成率增加，这些途径中关键代谢酶改变的直接后果，是目前公认的肿瘤细胞和代谢的一个重要方面。过去的几年中研究表明，一些原癌基因的突变或扩增与这一代谢失调有关。因此，剖析肿瘤的分子机制，将代谢重编程与上游改变信号联系起来是至关重要的。本文讨论了乳腺癌中脂质和蛋白质生物合成的重要性， 讨论生长因子信号转导与这些代谢过程中关键代谢酶之间的相互作用，指出了针对这些关键参数，以帮助乳腺癌患者提供新的治疗机会时，开发新的策略和治疗药物的潜力。
关键词: 乳腺癌，代谢，原癌基因，脂质，蛋白质，靶向治疗
图形摘要
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