Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus

Title: Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus

Volume: 7 Issue: 3

Author(s): Gwendoline C.L. Ee, Siow H. Teo, Mawardi Rahmani, Chan K. Lim, Yang M. Lim and Choon F.J. Bong

Affiliation:

Keywords: Artocarpus odoratissimus, moraceae, pyranoflavone, triterpenoid, cytotoxicity, antioxidant

Abstract: Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).

Cite this article as:

C.L. Ee Gwendoline, H. Teo Siow, Rahmani Mawardi, K. Lim Chan, M. Lim Yang and F.J. Bong Choon, Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus, Letters in Organic Chemistry 2010; 7 (3) . https://dx.doi.org/10.2174/157017810791112379