在老年斯里兰卡（科伦坡）和印度（班加罗尔）的大脑样本年龄相关性疾病的细胞骨架病理学

Title:Cytoskeletal Pathologies of Age-Related Diseases between Elderly Sri Lankan (Colombo) and Indian (Bangalore) Brain Samples

Volume: 13 Issue: 3

Author(s): Printha Wijesinghe, S. K. Shankar, Yasha T. Chickabasaviah, Catherine Gorrie, Dhammika Amaratunga, Sanjayah Hulathduwa and K. Sunil Kumara, Kamani Samarasinghe, Yoo Hun Suh, H. W. Steinbusch, K. Ranil D. De Silva

Affiliation:

关键词: AD的神经病理学改变，细胞丢失，免疫组织化学，帕金森，南亚，海绵状改变。

摘要: Within South Asia, Sri Lanka represents fastest aging with 13% of the population was aged over 60’s in 2011, whereas in India it was 8%. Majority of the Sri Lankan population based genetic studies have confirmed their origin on Indian mainland. As there were inadequate data on aging cytoskeletal pathologies of these two nations with their close genetic affiliations, we performed a comparison on their elderly. Autopsy brain samples of 50 individuals from Colombo, Sri Lanka (mean age 72.1yrs ± 7.8, mean ± S.D.) and 42 individuals from Bangalore, India (mean age 65.9yrs ± 9.3) were screened for neurodegenerative pathologies using immunohistochemical techniques. A total of 79 cases with incomplete clinical history (Colombo- 47 and Bangalore- 32) were subjected to statistical analysis and 13 cases, clinically diagnosed with dementia and/or Parkinsonism disorders were excluded. As per National Institute on Aging- Alzheimer’s Association guidelines, between Colombo and Bangalore samples, Alzheimer’s disease neuropathologic change for intermediate/ high level was 4.25% vs. 3.12% and low level was 19.15% vs. 15.62% respectively. Pathologies associated with Parkinsonism including brainstem predominant Lewy bodies- 6.4% and probable progressive supra nuclear palsy- 2.13% were found solely in Colombo samples. Alzheimer related pathologies were not different among elders, however, in Colombo males, neurofibrillary tangle grade was significantly higher in the region of hippocampus (odds ratio = 1.46, 95% confidence interval = 0.07-0.7) and at risk in midbrain substantia nigra (p = 0.075). Other age-related pathologies including spongiform changes (p < 0.05) and hippocampus cell loss in dentate gyrus region (p < 0.05) were also identified prominently in Colombo samples. Taken together, aging cytoskeletal pathologies are comparatively higher in elderly Sri Lankans and this might be due to their genetic, dietary and/ or environmental variations.

Cite this article as:

Printha Wijesinghe, S. K. Shankar, Yasha T. Chickabasaviah, Catherine Gorrie, Dhammika Amaratunga, Sanjayah Hulathduwa and K. Sunil Kumara, Kamani Samarasinghe, Yoo Hun Suh, H. W. Steinbusch, K. Ranil D. De Silva , Cytoskeletal Pathologies of Age-Related Diseases between Elderly Sri Lankan (Colombo) and Indian (Bangalore) Brain Samples, Current Alzheimer Research 2016; 13 (3) . https://dx.doi.org/10.2174/156720501303160217121210