Size-Dependent Differences in Biodistribution of Titanium Dioxide Nanoparticles After Sub-Acute Intragastric Administrations to Rats

Title:Size-Dependent Differences in Biodistribution of Titanium Dioxide Nanoparticles After Sub-Acute Intragastric Administrations to Rats

Volume: 12 Issue: 2

Author(s): Olga D. Hendrickson, Svetlana M. Pridvorova, Anatoly V. Zherdev, Sergey G. Klochkov, Oksana V. Novikova, Elena F. Shevtsova, Sergey O. Bachurin and Boris B. Dzantiev

Affiliation:

Keywords: Biodistribution, intragastric administration, sub-acute, titanium dioxide nanoparticles.

Abstract: Background: The human and environmental exposure to titanium dioxide is currently large-scale. Taking into account that for TiO2 the peroral route of exposure seems to be a very important route of exposure for humans, knowledge of its biodistribution and toxicity after the peroral uptake, is highly relevant for the human health risk assessment of TiO₂ NPs. The present study compares the biodistribution of titanium dioxide nanoparticles of different sizes (5-10 nm and 20-25 nm) after peroral administration to rats.

Methods: For comparison of the biodistributions of titanium dioxide nanoparticles, male rats were intragastrically administered with two specimens of TiO2 nanoparticles for a 28-day period at a daily dose of 250 mg/kg of body weight. Titanium dioxide was detected in rats` organs and tissues by atomic absorption spectroscopy.

Results: The absorption from the gastrointestinal tract (GIT) and translocation into secondary organs of titanium dioxide occurred in a size-dependent manner. After administration of the smaller nanoparticles, titanium was found in the brain, lungs, heart, liver, kidneys, spleen, small intestine, testicles, and blood (0.004–0.227 µg/g of organ), whereas after administration of the larger nanoparticles, titanium was accumulated only in the liver, kidneys, spleen, and small intestine (0.01– 0.29 µg/g of organ). The amounts of the detected titanium are much smaller than the administered doses. After repeateddose exposures, no animal deaths or toxicity indications were observed.

Conclusions: The penetration of titanium dioxide nanoparticles from the GIT of rats into the bloodstream and their translocation into secondary organs are size-dependent and has no evident toxic effect.

Cite this article as:

D. Hendrickson Olga, M. Pridvorova Svetlana, V. Zherdev Anatoly, G. Klochkov Sergey, V. Novikova Oksana, F. Shevtsova Elena, O. Bachurin Sergey and B. Dzantiev Boris, Size-Dependent Differences in Biodistribution of Titanium Dioxide Nanoparticles After Sub-Acute Intragastric Administrations to Rats, Current Nanoscience 2016; 12 (2) . https://dx.doi.org/10.2174/1573413711666151008013943