Ferulic Acid and Alzheimer’s Disease: Promises and Pitfalls

Title:Ferulic Acid and Alzheimer’s Disease: Promises and Pitfalls

Volume: 15 Issue: 9

Author(s): Seyed Fazel Nabavi, Kasi Pandima Devi, Dicson Sheeja Malar, Antoni Sureda, Maria Daglia and Seyed Mohammad Nabavi

Affiliation:

Keywords: Alzheimer’s disease, antioxidant, ferulic acid, neurodegeneration, oxidative stress.

Abstract: Oxidative stress plays an important role in both initiation and progression of neurodegenerative diseases, such as Alzheimer and Parkinson. Therefore, much attention has been paid to antioxidants for developing therapeutic strategies for the neurodegenerative diseases. However, as serious adverse effects are related to synthetic antioxidants, recent research has been focused on natural products especially phenolic antioxidants. In the present article, we critically review the available literature related to the beneficial role of ferulic acid on Alzheimer’s disease, since it is a natural antioxidant which is widely found in different fruits and vegetables. We also provide some informations about sources, chemical structure, bioavailability and clinical impacts of ferulic acid.

Cite this article as:

Fazel Nabavi Seyed, Pandima Devi Kasi, Sheeja Malar Dicson, Sureda Antoni, Daglia Maria and Mohammad Nabavi Seyed, Ferulic Acid and Alzheimer’s Disease: Promises and Pitfalls, Mini-Reviews in Medicinal Chemistry 2015; 15 (9) . https://dx.doi.org/10.2174/1389557515666150522102545