Synthetic Strategies for Aspartic and Glutamic Acid-Proline Chimeras: A Review

Title:Synthetic Strategies for Aspartic and Glutamic Acid-Proline Chimeras: A Review

Volume: 12 Issue: 3

Author(s): Azzurra Stefanucci, Roberto Costante, Simone Carradori, Ettore Novellino and Adriano Mollica

Affiliation:

Keywords: Aspartic acid, domoic acid, glutamic acid, kainic acid, peptidomimetics, proline chimeras.

Abstract: Proline chimeras are conformationally rigid amino acid analogues. Their application in medicinal chemistry for the synthesis of peptidomimetics is a well-known approach. Of particular interest are the natural Glu/Asp proline chimeras, namely Domoic acid and Kainic acid, for their toxic effect on the human health which have been used as probes for glutamatergic receptors studies. In this review, we analyze the most relevant synthetic approaches to Glu/Asp analogues.

Cite this article as:

Stefanucci Azzurra, Costante Roberto, Carradori Simone, Novellino Ettore and Mollica Adriano, Synthetic Strategies for Aspartic and Glutamic Acid-Proline Chimeras: A Review, Mini-Reviews in Organic Chemistry 2015; 12 (3) . https://dx.doi.org/10.2174/1570193X12666150320232731