A Dual Role for Sirtuin 1 in Tumorigenesis

Title:A Dual Role for Sirtuin 1 in Tumorigenesis

Volume: 20 Issue: 15

Author(s): Yujiang Fang and Michael B. Nicholl

Affiliation:

Keywords: Sirtuin1, tumor.

Abstract: Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it can function as either a tumor promoter or suppressor. Its function in malignancy varies with concentration, cellular location, temporal and spatial distribution, and regulation by upstream and downstream factors. In this mini-review, we present the existing data which implicates SIRT1 in tumorigenesis.

Cite this article as:

Fang Yujiang and Nicholl B. Michael, A Dual Role for Sirtuin 1 in Tumorigenesis, Current Pharmaceutical Design 2014; 20 (15) . https://dx.doi.org/10.2174/13816128113199990488