Abstract
A series of substituted cinnamic acid esters were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. Compound 8 was found to be the most potent inhibitor with IC50 value of 5.60µM. Preliminary structure activity relationships (SARs) were concluded. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 8 was anti-competitive inhibitor.
Keywords: Substituted cinnamic acid esters, Tyrosinase inhibitor, Synthesis, Structure activity relationships, Inhibition kinetics, Anti-competitive inhibitor.
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