Design, Synthesis and Evaluation of Arylidene Pyrrolo and Pyrido Fused Quinazolones as Antimicrobial Agents

Title:Design, Synthesis and Evaluation of Arylidene Pyrrolo and Pyrido Fused Quinazolones as Antimicrobial Agents

Volume: 10 Issue: 6

Author(s): Kunal Nepali, Ritu Ojha, Aninder Singh, Abhishek Budhiraja, Preet Mohinder Singh Bedi and Kanaya Lal Dhar

Affiliation:

Keywords: Antimicrobial, Quinazoline, Strains, Quinazoline, Pyrrolo, Pyrido.

Abstract: Keeping in view the potential of heterocyclic fused quinazolones and arylidene linked heterocycles , hybrid molecules of these functionalities were designed and synthesised. All the synthesised molecules were characterized by spectroscopic techniques and evaluated for antimicrobial activity against 2 Gram positive bacterial strains; Staphylococcus aureus (MTCC 96) and Bacillus subtilis (MTCC 2451), 3 Gram negative bacterial strains; Escherichia coli (MTCC 82), Pseudomonas aeruginosa (MTCC 2642) and Salmonella typhimurium (MTCC 1251) and 2 fungal strains; Saccharomyces cerevisiae (MTCC 2799) and Candida albicans (MTCC 3018). Among the synthesised molecules, arylidene pyrrolo fused quinazolones displayed significant antimicrobial activity in comparison to arylidene pyrido fused quinazolones. The influence of the electronic factors linked with the arylidene ring was also observed on the antimicrobial potential. Thus the present study highlights the potential of such hybrid molecules as a new class of antimicrobials.

Cite this article as:

Nepali Kunal, Ojha Ritu, Singh Aninder, Budhiraja Abhishek, Bedi Preet Mohinder Singh and Dhar Kanaya Lal, Design, Synthesis and Evaluation of Arylidene Pyrrolo and Pyrido Fused Quinazolones as Antimicrobial Agents, Letters in Drug Design & Discovery 2013; 10 (6) . https://dx.doi.org/10.2174/1570180811310060008

DOI https://dx.doi.org/10.2174/1570180811310060008	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X